Outcomes in children with intestinal failure following listing for intestinal transplant.

Journal of Pediatric Surgery
Oliver B LaoAdam B Goldin

Abstract

The purpose of this study was to describe the population of pediatric patients waiting for intestinal transplant and to evaluate the risk of death or transplant by specific disease states. We studied the United Network for Organ Sharing (UNOS) database (Jan 1,1991 to 5/16/08) for patients 21 years old or younger at first listing for intestinal transplant and examined their age, sex, weight, and diagnoses. Time to list removal was summarized with cumulative incidence curves. Multinomial logistic regression was used to compare relative risk ratios for removal from the list for transplant, death, or other reasons. We identified 1712 children listed for intestinal transplant (57% male, 51% <1 year, weight 8.1 kg [IQR, 6.1-14.1] at listing). Median age and weight at transplant (n = 852) were 1 year (IQR, 1-5) and 10 kg (IQR, 6.5-16.3). Regression analysis demonstrated significant differences in outcomes among disease conditions (P < .001). Compared to the gastroschisis group, the relative risk ratio for death versus transplant was higher in the necrotizing enterocolitis group (P = .015), lower in the short gut syndrome group (P = .001), and not different in the volvulus group (P = .94) after adjustment for weight and sex. We conclud...Continue Reading

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References

Jun 8, 1999·Journal of Pediatric Surgery·D JanY Révillon
Jun 27, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jonathan FryerMichael Abecassis
Feb 16, 2005·Current Opinion in Gastroenterology·Jonathan P Fryer
Mar 12, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·William E HarmonMary K Guidinger
Mar 31, 2005·Annals of Surgery·David GrantUNKNOWN Intestine Transplant Registry
Aug 16, 2006·Transplantation Proceedings·G SelvaggiA Tzakis
Nov 24, 2007·Journal of the American College of Surgeons·Neil ChungfatJonathan Fryer
May 14, 2008·Transplantation·Sameera I MianRicardo O Castillo

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Citations

Dec 3, 2014·Seminars in Pediatric Surgery·Frans W J HazebroekRene M H Wijnen
Feb 6, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ryan G Spurrier, Tracy C Grikscheit
Jan 21, 2015·Nature Reviews. Gastroenterology & Hepatology·Kareem Abu-Elmagd
Jun 7, 2019·The American Journal of Clinical Nutrition·Aureliane Chantal Stania PierretJake Peter Mann
Jul 11, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Alicia M AlcamoRajesh K Aneja

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