Outcomes in intervention and management of multiple pregnancies trials: A systematic review.

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Nicola FarmerR Katie Morris

Abstract

Twin pregnancy has risks of adverse outcomes for mother and baby. Data synthesis is required to gain evidence to aid recommendations but may be hampered by variations in outcome reporting. Systematically review outcomes reported in twin pregnancy trials (PROSPERO - CRD42019133805). Searches were performed in MEDLINE, EMBASE, CINHAL, Cochrane library (inception-January 2019) for randomised control trials or their follow-up studies reporting prediction, prognosis, intervention or management outcomes in twin pregnancy. The study characteristics, outcomes definitions and measurements were extracted and descriptively analysed. 49 RCTs and 8 follow-up studies evaluated 21 interventions, 1257 outcomes, categorised into 170 unique outcomes. 65 % of trials included all twin pregnancies, 12 % DCDA and 11 % MCDA only or MCMA and MCDA. Five (9 %) papers were prediction/ prognosis RCT's and 52 (91 %) related to an intervention. Of interventions, 40 (77 %) were medical, 34 (85 %) for preterm birth; 12 (23 %) surgical, 6 (50 %) related to TTTS interventions (83 % for monochrorionic studies). Commonest domains were: 'Neonatal' 77 %, 'Delivery' 70 % and 'Survival' 67 %. Least reported were longer term outcomes for 'Infant' or 'Parental'. Twin p...Continue Reading

References

Feb 14, 2004·BJOG : an International Journal of Obstetrics and Gynaecology·Simon Gates, Peter Brocklehurst
Jul 29, 2004·Best Practice & Research. Clinical Obstetrics & Gynaecology·Anita RaoHassan Shehata
Jan 8, 2008·Lancet·Robert L GoldenbergRoberto Romero
Jan 22, 2009·Obstetrics and Gynecology·Karien E HackGerard H Visser
Jan 5, 2013·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Bryce B ReeveZeeshan Butt
Jan 15, 2014·Lancet·John P A IoannidisRobert Tibshirani
Dec 30, 2014·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Samson Gebremedhin
Nov 13, 2015·Trials·Elizabeth GargonMike Clarke
Jul 7, 2017·Trials·Paula R WilliamsonBridget Young
Dec 31, 2017·Journal of Clinical Epidemiology·Susanna DoddPaula R Williamson
Mar 23, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R FishP R Williamson
Apr 24, 2018·International Journal of Colorectal Disease·R R van TolS O Breukink
Nov 22, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·P P SmithT J Clark
Dec 7, 2018·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·H PerryUNKNOWN International Collaboration to Harmonise Outcomes for Twin-Twin Transfusion Syndrome (CHOOSE)

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