Outcomes in occupational asthma caused by reactive dye after long-term avoidance

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
H-W ParkS-H Cho


Reactive dye (RD) is known to be a causative agent of occupational asthma (OA). However, to date, no report has been issued concerning the long-term outcomes of RD-induced OA. We sought to evaluate the long-term outcomes in cases of OA caused by RD. A total of 11 OA patients confirmed by RD bronchial challenge were enrolled in this study. First and second follow-up examinations were conducted at 4.3+/-2.3 and 13.7+/-2.3 years (means+/-SD) after the initial examinations, respectively. Skin prick test with RD and 11 common inhalant allergens, pulmonary function test, methacholine bronchial provocation testing, symptom and medication scores were determined at each visit. In addition, inflammatory cells in induced sputum were measured at the second follow-up examinations. Reduced lung function at initial examinations did not recover at the first and second examinations despite cessation of exposure and proper pharmacological treatment. In addition, asthma severity (as determined by symptom and medication scores) and non-specific airway hyper-responsiveness to methacholine also did not improve. However, skin reactivity to RD almost disappeared at the second examinations. Interestingly, four of the six patients who showed negative sk...Continue Reading


Jan 1, 1978·Clinical Allergy·K AlankoS Ojanen
Mar 1, 1991·The Journal of Allergy and Clinical Immunology·H S ParkC S Hong
May 1, 1987·The Journal of Allergy and Clinical Immunology·M Chan-YeungP L Paggiaro
Feb 1, 1995·American Journal of Respiratory and Critical Care Medicine·M SaettaA Di Stefano
Apr 1, 1996·Thorax·S Meredith, H Nordman
Feb 24, 1999·International Archives of Occupational and Environmental Health·S H Lee
Jan 7, 2000·The American Journal of Medicine·P D Blanc, K Toren
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·P L PiiriläM Tuppurainen
Feb 25, 2003·American Journal of Respiratory and Critical Care Medicine·John BalmesUNKNOWN Environmental and Occupational Health Assembly, American Thoracic Society
Apr 22, 2003·The Journal of Allergy and Clinical Immunology·Bich NguyenDenyse Gautrin
May 24, 2003·The European Respiratory Journal·M PadoanC E Mapp
Oct 28, 2003·American Journal of Respiratory and Critical Care Medicine·Karim MaghniJean-Luc Malo
Mar 15, 2005·Current Opinion in Allergy and Clinical Immunology·Jacques Ameille, Alexis Descatha
Apr 30, 2005·American Journal of Respiratory and Critical Care Medicine·Cristina E MappLeonardo M Fabbri

❮ Previous
Next ❯


May 13, 2010·Current Allergy and Asthma Reports·Olivier Vandenplas
Jun 13, 2012·International Journal of Environmental Research and Public Health·Sibel OzkurtSevin Baser
Jun 18, 2011·The Clinical Respiratory Journal·Paula KauppiRiitta Sauni
Jan 12, 2008·Current Opinion in Allergy and Clinical Immunology·Anneke ten Brinke
Apr 4, 2013·International Archives of Allergy and Immunology·Min-Hye KimHye-Ryun Kang
Jul 9, 2011·Allergy, Asthma & Immunology Research·Hyun Jung JinHae-Sim Park

❮ Previous
Next ❯

Related Concepts

Related Feeds


This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.