Abstract
Allogeneic stem cell transplantation is an alternative for patients with relapsed or refractory Hodgkin lymphoma (HL), but only limited data on unrelated umbilical cord blood transplantation (UCBT) are available. We analyzed 131 adults with HL who underwent UCBT in European Society for Blood and Marrow Transplantation centers from 2003 to 2015. Disease status at UCBT was complete remission (CR) in 59 patients (47%), and almost all patients had received a previous autologous stem cell transplantation. The 4-year progression-free survival (PFS) and overall survival (OS) were 26% (95% confidence interval [CI], 19% to 34%) and 46% (95% CI, 37% to 55%), respectively. Relapse incidence was 44% (95% CI, 36% to 54%), and nonrelapse mortality (NRM) was 31% (95% CI, 23% to 40%) at 4 years. In multivariate analysis refractory/relapsed disease status at UCBT was associated with increased relapse incidence (hazard ratio [HR], 3.14 [95% CI, 1.41 to 7.00], P = .005) and NRM (HR, 3.61 [95% CI, 1.58 to 8.27], P = .002) and lower PFS (HR, 3.45 [95% CI, 1.95 to 6.10], P < .001) and OS (HR, 3.10 [95% CI, 1.60 to 5.99], P = .001). Conditioning regimen with cyclophosphamide + fludarabine + 2 Gy total body irradiation (Cy+Flu+2GyTBI) was associated w...Continue Reading
References
Oct 1, 1974·Transplantation·H GlucksbergE D Thomas
Mar 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A SuredaUNKNOWN Grupo Español de Linformas/Transplante Autólogo de Médula Osea Spanish Cooperative Group
Jun 7, 2005·Lancet·Karl S PeggsStephen Mackinnon
Dec 31, 2005·Blood·Navneet S MajhailLinda J Burns
Jun 29, 2007·Leukemia·P CorradiniUNKNOWN Gruppo Italiano Trapianto di Midollo Osseo
Jan 16, 2008·Bone Marrow Transplantation·K J ThomsonS Mackinnon
Oct 23, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Lauri M BurroughsDavid G Maloney
Dec 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Celso A RodriguesVanderson Rocha
Jan 27, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Claudio G BrunsteinJohn E Wagner
Nov 5, 2010·The New England Journal of Medicine·Anas YounesAndres Forero-Torres
Dec 16, 2010·British Journal of Haematology·Paolo CorradiniLucia Farina
Jan 7, 2011·Annals of Hematology·Robert ChenAuayporn Nademanee
Oct 14, 2011·Haematologica·Anna SuredaNorbert Schmitz
Mar 29, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anas YounesRobert Chen
Oct 16, 2012·Haematologica·Adam GibbJohn Radford
Mar 30, 2013·Haematologica·Ambroise MarcaisNoel Milpied
Nov 5, 2013·Bone Marrow Transplantation·A RaiolaL Castagna
Dec 5, 2013·Hematological Oncology·Sylvain GarciazRéda Bouabdallah
Nov 18, 2014·Bone Marrow Transplantation·V BachanovaW Saber
Dec 9, 2014·The New England Journal of Medicine·Stephen M AnsellPhilippe Armand
Mar 23, 2015·Lancet·Craig H MoskowitzUNKNOWN AETHERA Study Group
Apr 8, 2015·European Journal of Haematology·José Luis PiñanaUNKNOWN GETH GITMO groups
Oct 17, 2015·Leukemia & Lymphoma·Philip A ThompsonChitra M Hosing
Jul 28, 2016·The Lancet Oncology·Anas YounesAndreas Engert
Jan 10, 2017·Bone Marrow Transplantation·J GauthierD Blaise
Jan 12, 2017·Blood·Reid W MerrymanPhilippe Armand
Jan 17, 2017·Bone Marrow Transplantation·L CastagnaD Blaise
Sep 30, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H BeközB Ferhanoglu
Nov 13, 2017·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jingmei HsuKoen van Besien
Dec 5, 2017·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jacopo MariottiLuca Castagna
Dec 26, 2017·The Lancet Oncology·Owen A O'ConnorJohn Kuruvilla
Feb 23, 2018·British Journal of Haematology·Ali BazarbachiAnna Sureda
Mar 10, 2018·Expert Review of Hematology·Avyakta Kallam, James O Armitage
May 4, 2018·Blood·Charles HerbauxBradley Haverkos