Abstract
To characterize the outcomes of patients with nonmelanoma solid tumors receiving anti-PD-1 immunotherapy not funded by the Australian Pharmaceutical Benefits Scheme. Medical records of patients with metastatic nonmelanoma tumor diagnoses treated with anti-PD-1 (self-funded pembrolizumab or nivolumab through an access program) from January 1, 2014, to December 31, 2016, at Peter MacCallum Cancer Centre, were retrospectively reviewed. Events after December 31, 2016, were censored. Of 47 patients identified, 27 (57%) had lung cancer. Twenty-six had compassionate access to nivolumab (24 lung, one renal, one gastroesophageal with possible new lung primary). Median overall survival was 5.7 months. Eleven (23%) achieved a partial response; none had complete response. Twenty (43%) had disease progression on first imaging; 16 (48%) of these continued treatment beyond radiological progression, with three achieving subsequent partial responses. Ten (21%) were not re-staged mostly due to rapid deterioration or death. At 6 and 12 months, nine (20%) and two (4%) remained on treatment, respectively. Five (12%) discontinued treatment due to immune-related toxicities. Of 34 patients who died, 71% received treatment within the last month of life...Continue Reading
References
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Craig C EarleSusan Block
Jun 2, 2015·The New England Journal of Medicine·Julie BrahmerDavid R Spigel
Sep 26, 2015·The New England Journal of Medicine·Robert J MotzerUNKNOWN CheckMate 025 Investigators
Sep 29, 2015·The New England Journal of Medicine·Hossein BorghaeiJulie R Brahmer
Dec 30, 2015·Lancet·Roy S HerbstEdward B Garon
Jun 9, 2016·Annals of Translational Medicine·Panagiota EconomopoulouAmanda Psyrri
Aug 25, 2016·Internal Medicine Journal·A J LomaxC McNeil
Dec 8, 2016·The Lancet Oncology·Geoffrey T GibneyMichael B Atkins
Jan 31, 2017·Cancers·Shilpa GuptaNeeraj Agarwal
Jul 7, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mizuki NishinoMark M Awad
Jul 25, 2017·Cancer Chemotherapy and Pharmacology·Hee Kyung KimMyung-Ju Ahn
Aug 2, 2017·ESMO Open·Deme John KarikiosMartin R Stockler
Aug 18, 2017·Melanoma Research·Akshjot Puri, Jade Homsi
Sep 6, 2017·Melanoma Research·Akihiko YukiTakuro Ishiguro