Outcomes of children following a first hospitalization for dilated cardiomyopathy

Circulation. Heart Failure
Seth A HollanderDavid Rosenthal

Abstract

We hypothesized that children with dilated cardiomyopathy who require hospital admission are at increased risk for death or transplantation during their first hospitalization and in the first year that follows. We also assessed the value of routine data collected during that time to predict death or the need for transplantation prior to discharge and within 1 year of admission. We conducted a retrospective review of 83 pediatric patients with dilated cardiomyopathy whose initial hospitalization fell between 2004 and 2009. The mean age at hospitalization was 7 years. The majority of patients demonstrated moderate or severe left ventricular dysfunction on initial echocardiogram (80%) and/or the need for intravenous inotropes within 7 days of hospital admission (69%). Five patients (6%) died, and 15 (18%) were transplanted in the initial hospitalization. At 1 year, 11/71 (15%) had died, and 27/71 (38%) were transplanted. The overall freedom from death, transplantation, or rehospitalization at 1 year following admission was 21%. Fractional shortening, left ventricular ejection fraction, serum cholesterol, uric acid, mixed venous saturation, and atrial filling pressures were all predictive of death or transplantation during the init...Continue Reading

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·L S TeradaJ E Repine
Sep 1, 1994·British Heart Journal·M BurchJ E Deanfield
Sep 29, 1998·Metabolism: Clinical and Experimental·F LeyvaA J Coats
Jan 14, 1999·European Heart Journal·F LeyvaA J Coats
Apr 25, 2003·The New England Journal of Medicine·Alan W NugentUNKNOWN National Australian Childhood Cardiomyopathy Study
Apr 25, 2003·The New England Journal of Medicine·Steven E LipshultzSteven D Colan
Nov 20, 2003·JAMA : the Journal of the American Medical Association·Douglas S LeeJack V Tu
Dec 10, 2003·Journal of the American College of Cardiology·Mathias RauchhausStefan D Anker
Jul 17, 2004·Arquivos brasileiros de cardiologia·Vitor Manuel Pereira AzevedoBernardo Rangel Tura
Jul 21, 2004·Journal of the American College of Cardiology·Anna E TsirkaCharles E Canter
Mar 15, 2006·Circulation·Wayne C LevyMilton Packer
Oct 19, 2006·JAMA : the Journal of the American Medical Association·Jeffrey A TowbinSteven E Lipshultz
Nov 23, 2006·Circulation·Piers E F DaubeneyUNKNOWN National Australian Childhood Cardiomyopathy Study
Jul 3, 2007·Journal of the American College of Cardiology·G Michael FelkerUNKNOWN CHARM Investigators
Sep 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Richard KirkMarshall I Hertz
Sep 21, 2010·Cardiology in the Young·Valentina GesueteFernando M Picchio
Sep 28, 2010·Heart Failure Clinics·Daphne T Hsu, Charles E Canter

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Citations

Dec 10, 2015·Expert Review of Cardiovascular Therapy·Paul F KantorSteven E Lipshultz
Feb 6, 2013·The American Journal of Emergency Medicine·Seth A HollanderDavid N Rosenthal
Jul 27, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mary Lynette SteinDavid N Rosenthal
Apr 5, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Susanna L den BoerMichiel Dalinghaus
Jun 18, 2014·Journal of Molecular and Cellular Cardiology·Kathryn C ChatfieldBrian L Stauffer
Jul 4, 2016·The Journal of Pediatrics·Brady S MoffettAntonio G Cabrera
Aug 18, 2016·The American Journal of Cardiology·Jack F PriceAyse Akcan-Arikan
Apr 7, 2017·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Takeshi MoriguchiAkiyasu Baba
Mar 16, 2017·World Journal of Cardiology·Imre J Pavo, Ina Michel-Behnke
Oct 18, 2013·Circulation. Heart Failure·Kimberly M MolinaUNKNOWN Pediatric Heart Network Investigators
Nov 21, 2013·Circulation. Heart Failure·Robb D Kociol
Sep 3, 2013·Current Opinion in Pediatrics·Debra A Dodd
Apr 18, 2020·Circulation. Heart Failure·Javier J LasaJack F Price
Jun 13, 2019·European Journal of Pediatrics·Muhammad Bassem Jammal AddinLindsey Hunter
Nov 28, 2017·The International Journal of Artificial Organs·Zaccaria RicciClaudio Ronco
Oct 19, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Stephanie J NakanoBrian L Stauffer
Feb 16, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Scott R AuerbachUNKNOWN Action Learning Network Investigators

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