Outcomes of children with infantile spasms after perinatal stroke

Pediatric Neurology
Meredith R GolombLinda S Williams

Abstract

The object of this study was to describe the outcomes of children with infantile spasms resulting from perinatal stroke. We used International Classification of Diseases, Ninth Revision (ICD-9) searches of billing records to identify 110 children with infantile spasms examined at our hospital from 1998 through 2005. Five of the 99 with symptomatic spasms (5%) had perinatal stroke. An additional five children with spasms caused by perinatal stroke were identified from pediatric stroke clinic records. Seven of the 10 children with spasms due to perinatal stroke presented with stroke as neonates. Three initially appeared healthy but were diagnosed with "presumed perinatal stroke" after radiographic imaging for their spasms evaluation. Median age at last follow-up was 6.3 years: 9 (90%) had epilepsy, 8 (80%) manifested cognitive impairment, and all (100%) had cerebral palsy. The three children who had delayed presentation of "presumed perinatal stroke" had better epilepsy and cognitive outcomes than the seven with neonatal presentation (P = 0.03). Perinatal stroke accounts for 5% of symptomatic spasms and results in high rates of chronic disability similar to those observed with other types of symptomatic spasms. However, a subgrou...Continue Reading

References

Sep 1, 1993·Pediatric Neurology·D A TraunerB Wulfeck
Jun 15, 1999·Epilepsia·E TrevathanM Yeargin-Allsopp
Aug 17, 2001·Annals of Neurology·M R GolombG A deVeber
Nov 6, 2004·Journal of Child Neurology·Meredith R GolombGabrielle A deVeber
Jun 23, 2005·Journal of Child Neurology·Meredith R GolombBhuwan P Garg

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Citations

Dec 12, 2007·Archives of Gynecology and Obstetrics·Franco BorrutoAlain Treisser
Nov 26, 2011·Pediatric Neurology·Alex R PaciorkowskiWilliam B Dobyns
Aug 4, 2009·Seminars in Fetal & Neonatal Medicine·Meredith R Golomb
Jan 22, 2008·Pediatric Neurology·Tasneem L TalibMeredith R Golomb
Dec 7, 2007·Pediatric Neurology·Mary Anne GuggenheimRichard A Hrachovy
Sep 25, 2007·The Journal of Pediatrics·Meredith R GolombLinda S Williams
Mar 29, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David Fernández-LópezZinaida S Vexler
Apr 11, 2008·Journal of Child Neurology·Catherine Zorn-OlexaMichel Fischbach
Jul 25, 2019·Journal of Child Neurology·Jason P LockrowCatherine Amlie-Lefond
Feb 6, 2021·Journal of Child Neurology·Ratika SrivastavaJerome Y Yager
Oct 18, 2020·Annals of Neurology·Chih-Hong LeeJohn W Swann
Feb 5, 2021·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Kristin R Hall, Meredith R Golomb

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