Outcomes of Combination Systemic and Intravitreal Antiviral Therapy for Acute Retinal Necrosis.

Ophthalmology Retina
Matthew R DebiecSteven Yeh

Abstract

Determine the efficacy of combination intravitreal and systemic antiviral therapy for the treatment of acute retinal necrosis (ARN) and risk factors impacting visual acuity (VA) and retinal detachment (RD) outcomes. Single-center retrospective case series. Patients with an ARN diagnosis based on clinical features and polymerase chain reaction confirmation who were treated at a tertiary referral, university-based academic practice. Patient records were reviewed for demographic information including age and gender. Snellen VA, disease findings including RD outcomes, optic nerve involvement, and treatments were recorded. Incidence rates of major VA and RD outcomes were calculated based on the number of events and exposure times. Cox proportional hazards regression modeling and survival analyses were used to identify factors related to VA and RD outcomes over time. Logarithm of the minimal angle of resolution VA, 2-line or more VA gain, severe vision loss (SVL) of 20/200 or worse, RD development, and fellow eye involvement. Twenty-three eyes of 21 patients (11 male, 10 female) were reviewed. Thirteen patients (62%) had herpes simplex virus and 8 patients (38%) had varicella zoster virus. The event rate for 2-line or more VA gain wa...Continue Reading

References

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Apr 20, 2014·JAMA Ophthalmology·Shlomit SchaalHenry J Kaplan
Sep 13, 2014·Ophthalmic Surgery, Lasers & Imaging Retina·Steven YehChristina J Flaxel
Jun 4, 2015·International Ophthalmology Clinics·Jessica G ShanthaSteven Yeh
Oct 17, 2015·Ocular Immunology and Inflammation·Meenakashi GuptaAnn-Marie Lobo

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Citations

Jul 10, 2021·Ocular Immunology and Inflammation·Sara L HojjatieSteven Yeh

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