Outcomes of concurrent chemoradiotherapy versus chemotherapy alone for advanced-stage unresectable intrahepatic cholangiocarcinoma

Radiation Oncology
Young-Il KimChang-Min Kim

Abstract

A standard treatment for unresectable advanced-stage intrahepatic cholangiocarcinoma (IHCC) has not yet been established. Although neoadjuvant concurrent chemoradiotherapy (CCRT) and liver transplantation are associated with long-term survival in select patients, the outcomes of CCRT for advanced-stage unresectable IHCC remain unclear. The aim of our study was to evaluate the outcomes of CCRT in patients with unresectable advanced-stage IHCC. We retrospectively reviewed the records of all patients with unresectable advanced stage (stage IVa or IVb) IHCC who were pathologically diagnosed and treated at National Cancer Center, Korea, from June 2001 to March 2012. Of the total of 92 patients, 25 (27.1%) received capecitabine plus cisplatin (XP) chemotherapy with external radiotherapy (RT) (XP-CCRT group) and 67 (72.8%) received XP chemotherapy alone (XP group). The clinical characteristics and outcomes of the 2 groups were compared. The 92 patients comprised 72 male and 20 female patients, with a median age of 58 years (range 26-78 years). The baseline clinical characteristics of the 2 groups were similar. Patients in the XP-CCRT group received a mean 44.7 Gy of RT and a mean 5.6 cycles of XP chemotherapy, whereas patients in the ...Continue Reading

References

Aug 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B GlimeliusC Svensson
Nov 22, 1997·International Journal of Radiation Oncology, Biology, Physics·M L FooS J Buskirk
Dec 31, 1997·American Journal of Surgery·K M McMastersS A Curley
Oct 28, 1999·The New England Journal of Medicine·P C de GroenD M Nagorney
May 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·I De VreedeG J Gores
Jun 8, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T Patel
Oct 5, 2001·Journal of the American College of Surgeons·S M WeberL H Blumgart
Jun 14, 2002·International Journal of Radiation Oncology, Biology, Physics·U N VaishampayanA F Shields
Jul 4, 2002·International Journal of Radiation Oncology, Biology, Physics·Christopher H CraneNora A Janjan
Sep 24, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Debra SudanAlan Langnas
Jul 11, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T W KimY K Kang
Feb 22, 2005·American Journal of Surgery·Harald PuhallaThomas Gruenberger
Oct 26, 2005·International Journal of Radiation Oncology, Biology, Physics·Francesco DeodatoAlessio G Morganti
Dec 5, 2006·Cancer Chemotherapy and Pharmacology·Yong Sang HongWon Ki Kang
Apr 9, 2010·The New England Journal of Medicine·Juan ValleUNKNOWN ABC-02 Trial Investigators
Jul 20, 2010·The Surgical Clinics of North America·George A PoultsidesTimothy M Pawlik
Dec 8, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Thomas B Brunner, Cynthia L Eccles
Dec 17, 2010·World Journal of Hepatology·Zenichi MoriseChinatsu Takeura
Apr 5, 2011·Nature Reviews. Gastroenterology & Hepatology·Tushar Patel
Apr 6, 2011·Journal of the American College of Surgeons·Johnny C HongRonald W Busuttil
Aug 3, 2011·Nature Reviews. Gastroenterology & Hepatology·Boris BlechaczGregory J Gores

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Citations

Jan 23, 2016·Journal of Surgical Oncology·Kerri A SimoJohn B Martinie
Sep 6, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Hajime MatsushimaSusumu Eguchi
Apr 1, 2014·Journal of Hepatology·John BridgewaterGregory J Gores
Mar 31, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Shin HwangSung-Gyu Lee
Aug 16, 2017·World Journal of Gastrointestinal Oncology·Hamzeh KayhanianChiara Braconi
Mar 8, 2018·World Journal of Surgery·Tatsuaki SumiyoshiTaijiro Sueda
Nov 26, 2019·American Journal of Clinical Oncology·Sheng-Ping HungJi-Hong Hong
Jul 30, 2020·Radiology and Oncology·Ilenia BartoliniPaolo Muiesan
Apr 21, 2017·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Yeona ChoJinsil Seong
Jan 12, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J MoreauJ Biau
Dec 18, 2020·Seminars in Interventional Radiology·Pouya Entezari, Ahsun Riaz
Jun 3, 2021·Journal of Clinical Medicine·Sudha KodaliRafik M Ghobrial

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Methods Mentioned

BETA
surgical resection

Software Mentioned

STATA

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