Outcomes of Conservative Management of High Grade Squamous Intraepithelial Lesions in Young Women

Journal of Lower Genital Tract Disease
Marette H LeeLeslie Ann Sadownik

Abstract

The aim of the study was to determine regression rates of cervical intraepithelial neoplasia (CIN) 2 and 3 in women younger than 24 years, followed conservatively for up to 24 months. This is a retrospective chart review of colposcopy patients in clinic database based on the following: (1) younger than 24 years at first visit; (2) first visit January 1, 2010, to May 31, 2013, and at least 1 follow-up visit after diagnosis; (3) histologic diagnosis of CIN2+; and (4) optimal conservative management (observation for up to 24 months or to 24 years, whichever occurred first). Patient information and clinical/pathologic data were extracted from charts to examine patient characteristics and treatment outcomes, CIN2+ regression rates, median times to regression for CIN2 versus CIN3 (Kaplan-Meier survival analysis), and predictors of regression (multivariate logistic regression analysis). A total of 154 women met criteria. The most severe histological diagnoses were CIN2 in 99 (64.3%), CIN3 in 51 (33.1%), and adenocarcinoma in situ in 4 (2.6%). Adenocarcinoma in situ was immediately treated. In follow-up, CIN2 regressed to CIN1 or negative in 74 women (74.7%)-median time to regression, 10.8 months. Cervical intraepithelial neoplasia 3 r...Continue Reading

References

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May 21, 2016·Journal of Lower Genital Tract Disease·Diede L LoopikJames R Bentley
Aug 3, 2016·Journal of Lower Genital Tract Disease·Peter SykesBryony Simcock
Sep 28, 2017·Journal of Lower Genital Tract Disease·Nicolas WentzensenL Stewart Massad

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Citations

Apr 4, 2020·Journal of Lower Genital Tract Disease·Rebecca B PerkinsUNKNOWN 2019 ASCCP Risk-Based Management Consensus Guidelines Committee
May 13, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Margot M KoenemanArnold J Kruse
Dec 31, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Hongyan RenSuzhen Fan
Sep 30, 2020·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Catriona BuickRachel Kupets
Jun 29, 2021·Journal of Lower Genital Tract Disease·Diede L LoopikJames R Bentley

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

SPSS
SPSS Statistics

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