Outcomes of Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplantation

The Annals of Thoracic Surgery
Yuliya TipografMatthew Bacchetta

Abstract

Extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation (BTT) has become a critical component of caring for patients with end-stage lung disease. This study examined outcomes of patients who received ECMO as a BTT. Statistical analysis was performed on data gathered retrospectively from the electronic medical records of adult patients who received ECMO as BTT at Columbia University Medical Center from April 2009 through July 2018. A total of 121 adult patients were placed on ECMO as BTT, and 70 patients (59%) were successfully bridged to lung transplantation. Simplified Acute Physiology Score II, unplanned endotracheal intubation, renal replacement therapy, and cerebrovascular accident were identified as independent predictors of unsuccessful BTT. Ambulation was the only independent predictor of successful BTT (odds ratio, 7.579; 95% confidence interval, 2.158 to 26.615; p = 0.002). Among the 64 patients (91%) who survived to hospital discharge, survival was 88% at 1 year and 83% at 3 years. Propensity matching between BTT and non-BTT lung transplant recipients did not show a significant difference in survival (log-rank = 0.53) despite significant differences in the lung allocation score (median, 92.2 [in...Continue Reading

Citations

Aug 14, 2019·JAMA : the Journal of the American Medical Association·Daniel BrodieAlain Combes
Jul 2, 2020·American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses·Whitney D GannonMatthew Bacchetta
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Jan 15, 2020·Respiratory Research·Ryoung-Eun KoUNKNOWN Korean Organ Transplantation Registry Study Group
Oct 25, 2020·Artificial Organs·Justyna SwolRoberto Lorusso
Jun 18, 2020·Journal of Cardiothoracic and Vascular Anesthesia·Archer Kilbourne MartinHarish Ramakrishna
Sep 2, 2020·The Annals of Thoracic Surgery·Benjamin J WadowskiZachary N Kon
Apr 15, 2021·Seminars in Neurology·Giovanni ChiariniRoberto Lorusso
Apr 13, 2021·Current Transplantation Reports·Basil S NasirMatthew Hartwig
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May 25, 2021·Seminars in Respiratory and Critical Care Medicine·Hanne BeeckmansRobin Vos
May 25, 2021·Seminars in Respiratory and Critical Care Medicine·John W StokesMatthew Bacchetta
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Aug 8, 2021·Journal of Clinical Medicine·Tomasz StącelMarek Ochman
Sep 5, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Jenna M GibilaroEmily DiMango

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