Outcomes of inflammatory bowel disease in patients with eosinophil-predominant colonic inflammation

BMJ Open Gastroenterology
Tarik AlhmoudDavid Martin

Abstract

Inflammatory bowel disease (IBD) is characterised by acute intestinal mucosal inflammation with chronic inflammatory features. Various degrees of mucosal eosinophilia are present along with the typical acute (neutrophil-predominant) inflammation. The effect of intestinal eosinophils on IBD outcomes remains unclear. This is a retrospective study. Archived intestinal mucosal biopsy specimens of treatment-naïve IBD patients were examined by two pathologists. The number of eosinophils per high-power field was counted, and the mucosal inflammation was classified according to the eosinophilic inflammatory patterns. Clinical outcomes during the follow-up period were recorded. 142 treatment-naïve IBD patients were included. Mean age was 39 years. 83% of patients had ulcerative colitis, and median follow-up was 3 years. 41% of patients had disease flare(s) and 24% required hospitalisation. Eosinophil count was not associated with risk of disease flare or hospitalisation. Patients with neutrophil-predominant inflammation (>70% neutrophils) had greater risk of disease flare(s): 27(55%) versus 24(36%) and 7(28%) in patients with mixed and eosinophil-predominant inflammation, respectively (p=0.04). Overall, patients with neutrophil-predomin...Continue Reading

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Citations

Dec 30, 2020·International Journal of Molecular Sciences·Reyes Gamez-BelmonteChristoph Becker
Mar 28, 2021·Seminars in Immunopathology·G CoakleyN L Harris
May 1, 2021·International Journal of Molecular Sciences·Eva Maria SturmGunther Marsche
Jun 14, 2021·Journal of Comparative Pathology·Antonia Morey-MatamalasKerstin Baiker
Aug 22, 2021·Inflammatory Bowel Diseases·Aamir JavaidSana Syed

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Methods Mentioned

BETA
light microscopy
biopsies
biopsy

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