Outcomes of intensive surveillance after resection of hepatic colorectal metastases

The British Journal of Surgery
D GomezK R Prasad

Abstract

The impact of computed tomography (CT)-based follow-up for the detection of resectable disease recurrence following surgery for colorectal liver metastases (CRLM) was evaluated. Some 705 patients undergoing resection of CRLM between January 1993 and March 2007 were included. Surveillance comprised 3-monthly CT (thorax, abdomen and pelvis) in the first 2 years after surgery, 6 monthly for 3 years and annually from years 6 to 10. Survival differences following recurrence between patients managed surgically and palliatively were determined, and the cost was calculated. Five-year disease-free and overall survival rates were 28.3 and 32.3 per cent respectively. Of 402 patients who developed recurrence within 2 years, 88 were treated with liver resection alone and 36 with lung and/or liver resection. Their 5-year overall survival rates were 31 and 30 per cent respectively, compared with 3.9 per cent in 278 patients managed palliatively (P < 0.001). For each 3-month interval during the first year of follow-up, patients with recurrence treated surgically had better overall survival than those treated palliatively. The cost of surveillance that identified 124 patients amenable to further resection was 12,338 pounds per operated recurren...Continue Reading

References

Sep 1, 1986·The British Journal of Surgery·H EkbergS Bengmark
Jan 1, 1995·World Journal of Surgery·J ScheeleM Paul
Nov 1, 1994·Annals of Surgery·Y FongM F Brennan
Aug 1, 1993·The British Journal of Surgery·K SugiharaT Takayama
Jun 1, 1996·Annals of Surgery·C W PinsonJ L Sawyers
Feb 1, 1997·The Surgical Clinics of North America·K W MillikanA Doolas
Feb 17, 2001·Journal of Hepato-biliary-pancreatic Surgery·J YamaguchiT Kanematsu
Feb 27, 2001·Journal of Surgical Oncology·A MuratoreL Capussotti
Aug 24, 2001·Journal of Surgical Oncology·S LyassO Jurim
Apr 30, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T Ruers, R P Bleichrodt
May 15, 2002·Diseases of the Colon and Rectum·C GloverT G Allen-Mersh
May 30, 2002·Annals of Surgery·Michael A ChotiJohn L Cameron
Jan 1, 2003·The Surgical Clinics of North America·Walter E Longo, Frank E Johnson
Mar 27, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·B TopalF Penninckx
May 8, 2003·The British Journal of Surgery·D EliasP Lasser
Jun 7, 2003·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M A Memon, I J Beckingham
Jun 24, 2005·ANZ Journal of Surgery·Matthew MetcalfeGuy Maddern
Nov 1, 2005·Journal of Hepato-biliary-pancreatic Surgery·Steven M Strasberg
May 2, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Nicolas VautheyEddie K Abdalla
Jun 10, 2006·Japanese Journal of Clinical Oncology·Shinichiro TakahashiTaira Kinoshita
Sep 30, 2006·Annals of Surgical Oncology·Süleyman YedibelaWerner Hohenberger
Jan 30, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H NishioJ P A Lodge
Dec 28, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·N N MehtaD F Mirza

❮ Previous
Next ❯

Citations

Sep 5, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Arthur J RichardsonHenry C C Pleass
Aug 1, 1990·Immunology Today·C G FigdorG D Keizer
Jan 27, 2011·World Journal of Gastrointestinal Oncology·Georgios TsoulfasIoannis Kanellos
Jun 21, 2013·Annals of Surgical Oncology·Sjoerd C BruinLaura J van't Veer
Jun 9, 2015·PET Clinics·Morsal SamimMarnix G E H Lam
Mar 6, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Fabio AusaniaDerek M Manas
Mar 6, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Andrea PelosoMarcello Maestri
Apr 24, 2012·Gastrointestinal Endoscopy·Piriyah SinclairAlla Amin
Mar 13, 2014·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Dhanwant GomezIain C Cameron
Jun 8, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Dhanwant GomezIain C Cameron
Aug 7, 2012·The British Journal of Surgery·R A AdairG J Toogood
Sep 12, 2013·European Journal of Radiology·Karin NielsenM Petrousjka van den Tol
Aug 12, 2014·BMC Medical Imaging·Karin NielsenPetrousjka M P van den Tol
Sep 7, 2016·The Lancet Oncology·James M FranklinFergus V Gleeson
Dec 21, 2016·Nature Reviews. Clinical Oncology·Eric P van der StokErnst J Kuipers
Apr 26, 2018·Annals of the Royal College of Surgeons of England·E MohamedD Gomez
Jan 16, 2019·World Journal of Gastroenterology : WJG·Shiru L Liu, Winson Y Cheung
Oct 3, 2020·World Journal of Gastrointestinal Oncology·Chuan-Zhuo WangZhao-Yu Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Christopher E DeschAmerican Society of Clinical Oncology
Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Loukia S PoulouLoukas Thanos
© 2021 Meta ULC. All rights reserved