Abstract
Intratumoral bleeding and/or intraperitoneal rupture occurs in up to 20% of patients with hepatocellular adenoma (HCA). Hepatectomy in the presence of haemorrhagic HCA has been associated with increased morbidity and mortality rates. This study evaluates the outcomes of hepatectomy for haemorrhagic HCA at a single institution. Between January 1997 and December 2012, 52 consecutive patients underwent liver resection for HCA. Among them, 14 patients were resected for haemorrhagic (H)-HCAs (including 9 cases of intratumoural bleeding and 5 cases of intraperitoneal bleeding) and 38 for non-haemorrhagic (NH)-HCAs. The preoperative characteristics were similar between the two groups except for younger age (p = .001) and shorter duration of hormonal use (p = .001) in (H)-HCAs. There were no mortalities. Intraoperative blood loss, transfusion rate, and postoperative morbidity were comparable between the two groups of patients (p = ns). The length of hospital stay was significantly longer in (H)-HCAs (p = .03). In all the resected H-HCAs, pathology showed central haemorrhagic changes with tumoral cells at the periphery of the lesions. Liver resection for H- and NH-HCAs can be achieved with no mortality and comparable short-term outcomes.
References
Aug 1, 1977·Gastroenterology·G Klatskin
Mar 14, 2000·Radiology·T IchikawaM Nalesnik
Feb 13, 2001·The British Journal of Surgery·T TerkivatanJ N IJzermans
Aug 15, 2001·Abdominal Imaging·C H HungH D Tung
Nov 1, 2005·Journal of Hepato-biliary-pancreatic Surgery·Steven M Strasberg
Apr 25, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Deha ErdoganThomas M van Gulik
Oct 20, 2006·The British Journal of Surgery·D J van der WindtJ N M IJzermans
Jul 3, 2007·Cardiovascular and Interventional Radiology·Deha ErdoganThomas M van Gulik
Aug 19, 2007·The British Journal of Surgery·J H M B StootA F M Schaapherder
Aug 13, 2008·Annals of Surgical Oncology·Sung W ChoT Clark Gamblin
Jan 9, 2009·Annals of Surgical Oncology·Jeremiah L DeneveDavid A Kooby
Jul 9, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paulette Bioulac-SageJean Saric
Aug 12, 2009·Gastroenterology·Safi DokmakJacques Belghiti
Apr 2, 2010·Digestive Surgery·Volkert A L Huurman, Alexander F M Schaapherder
Dec 15, 2010·Gut·Olivier FargesValérie Paradis
Aug 24, 2011·World Journal of Gastrointestinal Surgery·Mohammed Abu HilalNeil William Pearce
Mar 30, 2012·World Journal of Surgery·Masato NaritaPhilippe Bachellier
May 24, 2012·The British Journal of Surgery·S M van AaltenT Terkivatan
Apr 25, 2014·The British Journal of Surgery·M BiezeT M van Gulik
Citations
Aug 16, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Diamantis I TsilimigrasTimothy M Pawlik
Aug 28, 2020·BMJ Case Reports·Peter Daechul YoonHenry Pleass
Mar 2, 2019·World Journal of Hepatology·Marc SalhanickJustin R Parekh