Outcomes of multiple wire localization for larger breast cancers: when can mastectomy be avoided?

Journal of the American College of Surgeons
Laurie J KirsteinBarbara L Smith

Abstract

Mastectomy is often recommended when mammography shows a breast cancer with extensive calcifications. We wished to determine whether the use of multiple localizing wires to guide lumpectomy in this setting was associated with increased rates of breast conservation. We also wanted to identify factors that predicted a poor chance of successful lumpectomy, to avoid multiple lumpectomy attempts in a patient who would ultimately require mastectomy. Records of 153 women with breast cancer who underwent lumpectomy for larger lesions that required multiple wire localization and 196 controls who required only single wire localization were reviewed retrospectively. The number of localizing wires, specimen volume, largest specimen dimension, number of surgical procedures, and rates of breast conservation were scored. Seventy-seven percent of patients requiring multiple wire localization had successful breast conservation, compared with 90% of those needing only single wire localization. Only 28% of multiple wire patients required more than 1 excision to achieve clear margins, compared with 36% of single wire patients (p < 0.01). Breast conservation is possible in the great majority of breast cancer patients whose mammographic lesions requ...Continue Reading

References

Jul 29, 1976·The New England Journal of Medicine·H A FrankM L Steer
Feb 15, 1987·Cancer·M J SilversteinJ R Waisman
Nov 26, 1999·International Journal of Radiation Oncology, Biology, Physics·D E WazerH Safaii
Aug 23, 2001·AJR. American Journal of Roentgenology·L LibermanD D Dershaw
Sep 27, 2005·Journal of the American College of Surgeons·Melvin J SilversteinPat W Whitworth

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Citations

Oct 1, 2010·Annals of Surgical Oncology·Candy ArentzV Suzanne Klimberg
Mar 8, 2012·Annals of Surgical Oncology·Mona P Tan
Jul 24, 2014·AJR. American Journal of Roentgenology·Yingbing WangElizabeth Rafferty
Feb 2, 2012·International Journal of Breast Cancer·Dennis R HolmesRobina Smith
Nov 17, 2009·Academic Radiology·Caroline E BlaneMark A Helvie
Apr 29, 2015·The Breast : Official Journal of the European Society of Mastology·Caroline MalhaireFabien Reyal
Jan 8, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard J Bleicher
Oct 28, 2015·The British Journal of Surgery·N N Y JanssenM T F D Vrancken Peeters
Jun 10, 2021·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Leah R DickhoffTanja Alderliesten

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