Outcomes of node-negative breast cancer 5 centimeters and larger treated with and without postmastectomy radiotherapy

International Journal of Radiation Oncology, Biology, Physics
Jennifer GoulartAlan Nichol

Abstract

The role of adjuvant postmastectomy radiotherapy (PMRT) remains controversial for the rare presentation of pT3pN0cM0 breast cancer. The present analysis examined locoregional recurrence (LRR) and breast cancer-specific survival (BCSS) in pT2 = 5.0-cm and pT3 >5.0-cm tumors treated with mastectomy, stratified by PMRT use. Between January 1, 1989 and December 31, 2000, the British Columbia provincial database yielded 100 node-negative patients with tumors ≥ 5 cm of 19,846 nonmetastatic breast cancer patients (0.5%). Of these 100 patients, 44 (44%) had received adjuvant PMRT. The PMRT group contained significantly more pT3 >5-cm cases (p = 0.001) and margin-positive cases (p = .03). With a median follow-up of 10 years, the cumulative 10-year LRR rate was 2.3% (95% confidence interval, 0.2-10.5) in the PMRT group vs. 8.9% (95% confidence interval, 3.2-18.2) in the no-PMRT group (p = .2). Regarding LRR in the no-PMRT group, all patients had Grade 3 histologic features (LRR 17%, 5 of 29) and had not received hormonal therapy (LRR 15%, 5 of 34). The 10-year breast cancer-specific survival rate was 85.8% (95% confidence interval 71.0-93.4) in the PMRT group vs. 74.6% (95% confidence interval 59.9-84.5) in the no-PMRT group (p = .2). On...Continue Reading

References

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Citations

Feb 22, 2012·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Yasushi HamamotoMasaaki Kataoka
Jul 20, 2014·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·S M WalshJ Geraghty
Apr 30, 2013·Surgical Oncology Clinics of North America·Rachel C Blitzblau, Janet K Horton
Jul 6, 2014·Cancer·Matthew E JohnsonShelly B Hayes
Jan 26, 2017·The Breast Journal·Jonathan FrandsenMatthew M Poppe
Sep 11, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·James BundredNigel Bundred
May 22, 2021·Cancer Management and Research·Chunyan LiXiaomao Guo

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