Outcomes of pancreas transplantation in older diabetic patients

BMJ Open Diabetes Research & Care
Enrique Montagud-MarrahiPedro Ventura-Aguiar

Abstract

Improvement in insulin alternatives is leading to a delayed presentation of microvascular and macrovascular complications of diabetes. The objective of this study was to evaluate the long-term outcomes of older (≥50 years) diabetic patients who receive a pancreas transplantation (PT). We retrospectively evaluated all 338 PTs performed at our center between 2000 and 2016 (mean follow-up 9.4±4.9 years). Recipient and graft survivals were estimated for up to 10 years after PT. Major adverse cardiovascular events (MACEs) before and after PT were included in the analysis. Thirty-nine patients (12%) were ≥50 years old (52.7±2.3 years) at the day of PT, of which 29 received a simultaneous pancreas-kidney transplantation (SPK) and 10 a pancreas after kidney transplantation (PAK). SPK recipients were first transplants, whereas in the PAK up to 50% were pancreas re-transplantations. Recipient and pancreas graft survivals at 10 years were similar between the group <50 years old and the older group for both SPK and PAK (log-rank p>0.05). The prevalence of MACE prior to PT was similar between both groups (31% vs 29%). Following PT, older recipients presented inferior post-transplant MACE-free survival. In a multivariate regression model, di...Continue Reading

Citations

Dec 18, 2020·Current Opinion in Organ Transplantation·Surakshya RegmiRafael Villicana
Feb 12, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Franka MessnerChristian Margreiter
Dec 21, 2020·Cirugía española·María Argente-PlaJuan Francisco Merino-Torres
Apr 14, 2021·Seminars in Cardiothoracic and Vascular Anesthesia·Ryan F WangTetsuro Sakai
May 17, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Aleksandra KuklaMichael R Rickels

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Methods Mentioned

BETA
amputation
amputations

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SPSS

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