Outcomes of patients admitted to intensive care units for acute manifestation of small-vessel vasculitis: a multicenter, retrospective study

Critical Care : the Official Journal of the Critical Care Forum
Antoine KimmounBruno Lévy

Abstract

The outcomes of patients admitted to the intensive care unit (ICU) for acute manifestation of small-vessel vasculitis are poorly reported. The aim of the present study was to determine the mortality rate and prognostic factors of patients admitted to the ICU for acute small-vessel vasculitis. This retrospective, multicenter study was conducted from January 2001 to December 2014 in 20 ICUs in France. Patients were identified from computerized registers of each hospital using the International Classification of Diseases, Ninth Revision (ICD-9). Inclusion criteria were (1) known or highly suspected granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, microscopic polyangiitis (respectively, ICD-9 codes M31.3, M30.1, and M31.7), or anti-glomerular basement membrane antibody disease (ICD-9 codes N08.5X-005 or M31.0+); (2) admission to the ICU for the management of an acute manifestation of vasculitis; and (3) administration of a cyclophosphamide pulse in the ICU or within 48 h before admission to the ICU. The primary endpoint was assessment of mortality rate 90 days after admission to the ICU. Eighty-two patients at 20 centers were included, 94% of whom had a recent (<6 months) diagnosis of small-vessel va...Continue Reading

References

Jan 29, 2005·Intensive Care Medicine·Mickaël MoreelsMarc Leeman
Mar 19, 2005·Critical Care : the Official Journal of the Critical Care Forum·David SempleRichard Venn
Jun 22, 2007·Journal of the American Society of Nephrology : JASN·David R W JayneUNKNOWN European Vasculitis Study Group
Oct 16, 2008·The American Journal of the Medical Sciences·Fernando HolguinJesse Roman
Dec 5, 2008·Annals of the Rheumatic Diseases·C MukhtyarR A Luqmani
Dec 3, 2009·JAMA : the Journal of the American Medical Association·Jean-Louis VincentUNKNOWN EPIC II Group of Investigators
Jul 22, 2010·The New England Journal of Medicine·Rachel B JonesUNKNOWN European Vasculitis Study Group
Jul 22, 2010·The New England Journal of Medicine·John H StoneUNKNOWN RAVE-ITN Research Group
Oct 10, 2012·Arthritis and Rheumatism·J C JennetteR A Watts
Feb 5, 2013·Scandinavian Journal of Rheumatology·Z HruskovaD R W Jayne
Oct 3, 2013·BMC Anesthesiology·Patrice BefortKada Klouche
May 23, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ulrich Specks

❮ Previous
Next ❯

Citations

Oct 17, 2017·Stroke; a Journal of Cerebral Circulation·Mahmud Mossa-BashaChun Yuan
Dec 12, 2018·Current Opinion in Critical Care·Aude GibelinNicolas de Prost
Jan 11, 2017·Anaesthesia and Intensive Care·M BeilP V van Heerden
Apr 27, 2017·Intensive Care Medicine·Michael DarmonMiet Schetz
Feb 10, 2021·Annals of Intensive Care·Pierre BayMarc Pineton de Chambrun

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT00987389

Software Mentioned

GraphPad
Prism
SPSS Statistics

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
C H JonesA M Davison
Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
Hiroshi OguraJapanese Association for Acute Medicine Sepsis Registry (JAAMSR) Study Group
© 2021 Meta ULC. All rights reserved