Outcomes of patients after aborted radical cystectomy for intraoperative findings of metastatic disease

BJU International
Thomas J GuzzoMark L Gonzalgo

Abstract

To assess the clinical outcome of patients with bladder cancer who underwent attempted radical cystectomy (RC) with curative intent, but whose procedures were aborted due to intraoperative findings of metastatic disease, as the presence of metastatic disease at RC is associated with a poor prognosis and there are no data on the optimum management strategy in this situation. In all, 248 consecutive patients with bladder cancer had attempted RC at one academic institution between 1994 and 2003. We retrospectively reviewed the records of 35 patients who had an aborted RC due to intraoperative findings of metastatic disease. The pathological characteristics, time to recurrence, overall survival, disease-specific survival, and suitability for adjuvant or salvage therapies were examined. Of the 35 patients who had an aborted RC for metastatic disease, 21 (60%) died from the disease within the study period (median time to cancer-specific death 26.4 months), 11 (31%) are alive with evidence of persistent disease or progression, and three (9%) are alive with no evidence of recurrence or progression. Seven patients had a salvage RC after successful adjuvant treatment, of whom three died from recurrent disease (at a mean of 46.5 months af...Continue Reading

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Citations

Dec 17, 2008·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·T Lebret, A Méjean
Oct 5, 2013·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·Y NeuzilletUNKNOWN les membres du Comité de cancérologie de l’Association française d’urologie
Oct 24, 2018·Frontiers in Surgery·Francesco CattaneoFabrizio Dal Moro
May 8, 2021·Hematology/oncology Clinics of North America·Vivek Venkatramani, Dipen Jaysukhlal Parekh

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