Outcomes of patients receiving a massive transfusion for major trauma

The British Journal of Surgery
A EndoY Otomo

Abstract

The benefits of high transfusion ratios (plasma to red blood cells and platelets to red blood cells) on survival in injured patients who receive massive transfusions remain uncertain. This study aimed to assess the association between transfusion ratios and adverse events and survival in patients undergoing massive transfusion for major trauma. A retrospective observational study was conducted on patients who had major trauma using a Japanese national administrative database. The associations between transfusion ratios and outcomes (in-hospital mortality and incidence of adverse events) were analysed using a non-linear logistic generalized additive model (GAM). In a logistic generalized estimating equation model, adjusted for patient and hospital-level confounders, transfusion ratios were included as continuous or categorical variables (low, transfusion ratio 0·75 or less; intermediate, over 0·75 to 1·25; high, over 1·25). Some 1777 patients were included in the analysis, of whom 602 died in hospital. GAM plots of the transfusion ratios for in-hospital mortality demonstrated a downward convex unimodal curve. In-hospital mortality was similar with increasing transfusion ratios for plasma (adjusted odds ratio (OR) 1·13, 95 per ce...Continue Reading

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Citations

Jun 25, 2020·Revista da Associação Médica Brasileira·João Carlos Pina FariaAlexandre Szulman
Jan 26, 2020·Annals of Biomedical Engineering·Balaji RengarajanEnder A Finol
Nov 20, 2020·Acute Medicine & Surgery·Hiroyuki OtsukaSadaki Inokuchi
Apr 2, 2021·Dimensions of Critical Care Nursing : DCCN·Cristina Estebaranz-SantamaríaAzucena Pedraz-Marcos

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