Outcomes of Patients With Cirrhosis Undergoing Orthopedic Procedures: An Analysis of the Nationwide Inpatient Sample

Journal of Clinical Gastroenterology
Neehar D ParikhAmit K Mathur

Abstract

The population of patients with cirrhosis is growing and shifting toward a more elderly demographic and thus are at risk of developing orthopedic complications. There is lack of data on safety of orthopedic procedures in this population. We performed an analysis of the Nationwide Inpatient Sample from 2005 to 2011 for patients undergoing hip arthroplasty, knee arthroplasty, and spinal laminectomy/fusion, stratified by presence of cirrhosis. The primary endpoint was in-hospital mortality and secondary endpoints included length of stay (LOS) and costs. There were 693,610 inpatient stays for orthopedic procedures conducted during the study period, with 3014 (0.43%) patients coded as having cirrhosis. Patients with cirrhosis had a lower median age (62 vs. 66 y; P<0.001) and were more likely to be male (52.3% vs. 41.1%; P<0.001). The inpatient mortality rate was significantly higher in patients with cirrhosis (2.4% vs. 0.4%; P<0.001) as was median LOS (4 vs. 3 d; P<0.001) and mean costs ($19,321 vs. $18,833; P<0.001). Patients with decompensated cirrhosis (vs. compensated cirrhosis) had significantly higher inpatient mortality rates (5.8% vs. 1.1%; P<0.001) with higher LOS and costs (P<0.001). On multivariable analysis, cirrhosis wa...Continue Reading

References

Jun 1, 1992·Journal of Clinical Epidemiology·R A DeyoM A Ciol
Apr 12, 2002·The New England Journal of Medicine·John D BirkmeyerDavid E Wennberg
May 1, 2004·The Journal of Bone and Joint Surgery. American Volume·Olivier EthgenJean-Yves Reginster
Aug 30, 2005·The Journal of Arthroplasty·Stanley Martin CohenJosh Levitsky
Apr 6, 2007·Gastroenterology·Swee H TehPatrick S Kamath
Feb 21, 2009·Journal of the American College of Surgeons·Nicholas G CsikeszShimul A Shah
Dec 29, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Dana A TelemCelia M Divino
Sep 8, 2010·Health Services Research·Jonas Schreyögg, Tom Stargardt
Oct 20, 2010·Gastroenterology·Paul AnguloAlvaro Koch
Mar 29, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E Redondo-CerezoJ L Gonzalez-Calvin
Apr 9, 2014·Clinical Orthopaedics and Related Research·Shirley L JiangKevin J Bozic
Jul 6, 2014·Clinical Orthopaedics and Related Research·John V TiberiHany Bedair
Oct 8, 2014·Journal of Clinical Gastroenterology·Steven ScaglioneMichael L Volk
Mar 31, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Elliot B TapperNeil Sengupta
Apr 29, 2015·World Journal of Hepatology·Juan C Lopez-DelgadoMaria L Carrio
May 20, 2015·Obesity Surgery·Ahmad JanKamal K Mahawar
Feb 5, 2016·World Journal of Gastrointestinal Surgery·Doris WagnerTimothy M Pawlik
Mar 15, 2016·World Journal of Gastroenterology : WJG·Juan C Lopez-DelgadoCasimiro Javierre
Nov 22, 2016·Annals of Translational Medicine·Ram K AlluriNathanael Heckmann
Feb 18, 2018·The American Journal of Medicine·Ghideon EzazElliot B Tapper

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Methods Mentioned

BETA
total hip arthroplasty

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