Outcomes of Pediatric ABO-incompatible Living Kidney Transplantations From 2002 to 2015: An Analysis of the Japanese Kidney Transplant Registry

Transplantation
Motoshi HattoriJapan Society for Transplantation and Japanese Society for Clinical Renal Transplantation

Abstract

Extensive data have been accumulated for adults who have undergone ABO-incompatible (ABOi)-living kidney transplantation (LKT). In contrast, available published data on pediatric recipients who underwent ABOi-LKT from the early to middle 2000s is very limited. Thus, pediatric ABOi-LKT has remained relatively rare, and there is a lack of large, multicenter data. We analyzed data from the Japanese Kidney Transplant Registry to clarify the patient and graft outcomes of pediatric recipients who underwent ABOi-LKT from 2002 to 2015. A total of 102 ABOi and 788 ABO-compatible (ABOc) recipients were identified in this study. All recipients had received basiliximab and a triple immunosuppressive protocol comprising calcineurin inhibitors, mycophenolate mofetil, and steroids. The ABOi recipients also received preconditioning therapies including B-cell depletion by a splenectomy or rituximab treatment and therapeutic apheresis. Death rates for ABOi and ABOc recipients were 0.17 versus 0.17 deaths per 100 patient-years. Graft loss rates for ABOi and ABOc recipients were 1.58 versus 1.45 events per 100 patient-years. No particular causes of death or graft loss predominantly affected ABOi or ABOc recipients. The results of this registry ana...Continue Reading

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Citations

Feb 20, 2019·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Yuko HamasakiSeiichiro Shishido
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Feb 5, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hideki BanMotoshi Hattori
Jan 13, 2021·Scientific Reports·Yoko TakagiMotoshi Hattori

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