Outcomes of Pituitary Radiation for Cushing's Disease

Endocrinology and Metabolism Clinics of North America
Natasha IronsideJason P Sheehan

Abstract

Achievement of biochemical remission with preservation of normal pituitary function is the goal of treatment for Cushing's disease. For patients with persistent or recurrent Cushing's disease after transsphenoidal resection, radiation therapy may be a safe and effective treatment. Stereotactic radiosurgery is favored over conventional fractionated external beam radiation. Hormonal recurrence rates range from 0% to 36% at 8 years after treatment. Tumor control rates are high. New pituitary hormone deficiency is the most common adverse effect after stereotactic radiosurgery and external beam radiation. The effects of radiation planning optimization and use of adjuvant medication on endocrine remission rates warrant investigation.

Citations

Nov 16, 2019·Journal of Clinical Medicine·Hiroshi Nishioka, Shozo Yamada
Aug 25, 2020·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Adriana Albani, Marily Theodoropoulou
Apr 6, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Monica Livia Gheorghiu
Apr 6, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Tyler CardinalJohn D Carmichael
Feb 10, 2020·Best Practice & Research. Clinical Endocrinology & Metabolism·Amandine Ferriere, Antoine Tabarin

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