Outcomes of placebo therapy in inflammatory bowel disease

Inflammatory Bowel Diseases
C Su

Abstract

Placebo is important in assessing drug response, particularly in diseases characterized by spontaneous periods of acute exacerbation and quiescence. Randomized, placebo-controlled trials are the most objective means of evaluating drug efficacy, although the conduct of such clinical trials may not always be practical or ethical in all disease states. In inflammatory bowel disease (IBD), most patients experience intermittent episodes of active disease alternating with variable periods of remission. Thus, development of new medical therapies for IBD requires proof of superiority to placebo or alternative therapies. In this regard, knowledge of the outcomes of patients receiving placebo therapy and their influencing factors is important for proper study design and meaningful results. Such knowledge also is essential for interpreting results of open-label studies often necessary before randomized controlled trials can be conducted. In addition, the disease course of placebo-treated patients in clinical trials of IBD serves as an approximation of the natural history of these patients. The knowledge of placebo response in these patients provides clinicians with an important piece of information in prognosticating and making management...Continue Reading

References

Feb 1, 1989·Journal of Clinical Gastroenterology·S Meyers, H D Janowitz
Dec 24, 1987·The New England Journal of Medicine·K W SchroederD M Ilstrup
Aug 1, 1982·European Journal of Clinical Investigation·E A FaganM B Pepys
Jul 15, 1995·Annals of Internal Medicine·D C PearsonL R Sutherland
Apr 1, 1993·Journal of Clinical Gastroenterology·A A KornbluthH D Janowitz
Apr 1, 1997·Gastroenterology·A T Axon
Jun 1, 1997·Gastroenterology·A IlnyckyjC N Bernstein
Nov 9, 2000·Alimentary Pharmacology & Therapeutics·C PapiL Capurso
May 24, 2001·The New England Journal of Medicine·A Hróbjartsson, P C Gøtzsche
Mar 1, 1964·American Journal of Psychotherapy·A K SHAPIRO
May 27, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S M PatelA J Lembo
Sep 7, 2005·Gastroenterology·Stefan SchreiberUNKNOWN CDP870 Crohn's Disease Study Group

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Citations

Sep 29, 2009·European Journal of Internal Medicine·Sara RennaMario Cottone
Jan 19, 2007·Alimentary Pharmacology & Therapeutics·J P GisbertJ Maté
Sep 6, 2012·Journal of Internal Medicine·J Marsal, W W Agace
Feb 27, 2008·Inflammatory Bowel Diseases·Andrea AltschulerLisa J Herrinton
Jul 18, 2008·The British Journal of Nutrition·Raquel RochaAndre Castro Lyra
Mar 27, 2009·World Journal of Gastroenterology : WJG·Giovanni-C ActisFloriano Rosina
Jun 14, 2017·The Lancet. Gastroenterology & Hepatology·Gerhard Rogler

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