Outcomes of pregnancies complicated by beta-thalassemia/hemoglobin E disease

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Suchaya LuewanTheera Tongsong


To assess the outcomes of pregnancies affected by beta-thalassemia/hemoglobin E (beta-thal/HbE) disease. A retrospective cohort study was conducted with 54 women with singleton pregnancies complicated by beta-thal/HbE disease only. The controls-to-cases ratio was 2:1. Although maternal outcomes were similar in both groups, gestational age at birth and birth weight were significantly lower in the study group and the cesarean delivery rate was significantly higher in that group (relative risk [RR], 2.1). The incidences of fetal growth restriction, preterm birth, and low birth weight were also significantly higher in the study group, with RRs of 2.8, 2.7, and 5.6, respectively. Pregnancies affected by beta-thal/HbE disease were significantly associated with an increased risk of fetal growth restriction, preterm birth, and low birth weight.


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Related Concepts

Fetal Growth Retardation
Hemoglobin E
Low Birth Weight Infant
Neonatal Prematurity
Pregnancy Complications, Hematologic
Pregnancy Outcome
Retrospective Studies
Incidence Studies
Thalassemia Minor
High-Risk Pregnancy

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