Abstract
As their long-term prognosis improves, women with CF are increasingly choosing to have children, but the safety of CFTR modulators in pregnancy and breastfeeding is currently unknown. A survey was sent to lead clinicians of adult CF centres in Europe, the United Kingdom (UK), United States of America (USA), Australia and Israel requesting anonymised data on pregnancy outcomes in women using CFTR modulators before and during pregnancy and lactation. We identified 64 pregnancies in 61 women taking IVA (n = 31), LUM/IVA (n = 26) or TEZ/IVA (n = 7), resulting in 60 live births. In 44 pregnancies, CFTR modulators were either continued throughout pregnancy or temporarily stopped and then restarted. Two maternal complications were deemed related to CFTR modulator therapy; cessation of modulator therapy resulted in clinical decline in 9 women prompting resumption of therapy during pregnancy. No modulator-related complications were reported in infants exposed in utero and/or during breastfeeding. CFTR modulators were reported to be generally well tolerated in pregnancy and breastfeeding, with only 2 maternal complications that were deemed related to CFTR modulator therapy. Women stopping CFTR modulators in pregnancy may experience a dec...Continue Reading
Citations
Aug 23, 2020·Journal of Clinical Medicine·Jennifer L Taylor-Cousar
Jul 31, 2020·Nature·Elie Dolgin
Sep 18, 2020·Current Opinion in Pulmonary Medicine·Katherine B FraymanScott C Bell
Dec 1, 2020·Expert Review of Respiratory Medicine·Peter G Middleton, Jennifer L Taylor-Cousar
Dec 31, 2020·Journal of Clinical Medicine·Renée V E DagenaisBradley S Quon
Jan 12, 2021·Expert Opinion on Drug Delivery·Douweh Leyla Gbian, Abdelwahab Omri
Feb 4, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Kathleen J RamosJennifer L Taylor-Cousar
Mar 26, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Jennifer L Taylor-Cousar, Raksha Jain
Apr 10, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Peter G Middleton
Jun 3, 2021·Journal of Personalized Medicine·Raksha Jain, Jennifer L Taylor-Cousar
Dec 24, 2020·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Kate E O'ConnorGeorge M Solomon
May 25, 2021·Acta Obstetricia Et Gynecologica Scandinavica·Rita F PadoanGiuseppe Campagna
Jul 2, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Fiona QiuElena K Schneider-Futschik
Aug 7, 2021·Clinics in Chest Medicine·Raksha JainJennifer L Taylor-Cousar
Aug 19, 2021·Pediatric Pulmonology·Danielle M Goetz, Adrienne P Savant
Aug 19, 2021·Pediatric Pulmonology·Traci M KazmerskiJennifer L Taylor-Cousar
Jul 21, 2021·Chest·Michal ShteinbergMalena Cohen-Cymberknoh
Oct 20, 2020·ACS Pharmacology & Translational Science·Fiona QiuElena K Schneider-Futschik
Aug 31, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Raksha JainJennifer L Taylor-Cousar