Abstract
Therapeutic hypothermia reduces the risk of death, or moderate to severe neurodevelopmental impairment (NDI) in term infants with hypoxic-ischemic encephalopathy (HIE). Reports of its safety and efficacy in preterm infants are scarce. Report short and long-term outcomes of preterm infants with HIE who received therapeutic hypothermia. A retrospective cohort analysis of all preterm infants <36 weeks' gestation with HIE who received whole body hypothermia in a single center from January 2007 to April 2015. The primary outcome was death or moderate to severe NDI defined by moderate or severe cerebral palsy, severe hearing or visual impairment, or cognitive score < 85 on the Bayley Scales of Infant Development III (BSID III) at 18-24 months' adjusted age. 30 infants with a median gestational age and birthweight of 35 weeks' (range; 33-35) and 2575 g (1850-4840) and a median first postnatal blood pH of 6.81 (6.58-7.14). Complications included coagulopathy (50%), early clinical seizures (43.3%), arterial hypotension (40%), persistent metabolic acidosis (37%) and thrombocytopenia (20%). Four infants died before or soon after discharge (18.2%). Eighteen surviving infants (69.2%) had follow up data; 7 of them had moderate to severe NDI ...Continue Reading
Citations
Jun 13, 2019·Journal of Neurochemistry·Kenan LiChanglian Zhu
Aug 23, 2019·Acta Paediatrica·Stamatios GiannakisUNKNOWN German Neonatal Hypothermia Network
Sep 8, 2019·Pediatric Research·Lara PavageauLina F Chalak
May 5, 2018·Beneficial Microbes·A F AthiyyahS M Sudarmo
Jun 2, 2020·Frontiers in Pharmacology·Anne SmitsKarel Allegaert
Jun 4, 2019·Frontiers in Physiology·Julia C ShawHannah K Palliser
Jun 12, 2020·Journal of Neuroinflammation·Xiao HuJohn H Zhang
Jun 26, 2020·Frontiers in Cellular Neuroscience·Juan Carlos FernándezAlfredo Martínez
Nov 12, 2019·Frontiers in Pharmacology·Clare Yuen Zen LeeShaun Wen Huey Lee
Nov 12, 2020·Expert Review of Neurotherapeutics·Francesco PisaniCarlotta Spagnoli
Nov 4, 2020·Journal of Perinatal Medicine·Katherine CarltonSusan S Cohen
Jan 9, 2021·Molecular Neurobiology·Felipe Kawa OdorcykC A Netto
Jan 30, 2021·Therapeutic Hypothermia and Temperature Management·Barbara MichniewiczDawid Szpecht
Oct 12, 2020·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Lavanya RavichandranChristy G Woolcott
Nov 19, 2020·Journal of Neuroscience Research·Han QiuLaishuan Wang
Feb 11, 2021·International Journal of Molecular Sciences·Nathanael YatesJoanne O Davidson
Mar 10, 2021·Archives of Disease in Childhood. Fetal and Neonatal Edition·Lara ShipleyDon Sharkey
Sep 30, 2020·Neurología : publicación oficial de la Sociedad Española de Neurología·A Garcia-AlixUNKNOWN Grupo Cerebro Neonatal
Apr 22, 2021·Pediatric Research·Aisling A GarveyGeraldine B Boylan
Apr 27, 2021·Frontiers in Pharmacology·Manuel Rey-FunesAlfredo Martínez
Aug 28, 2021·Healthcare·Hanne LademannDirk Olbertz