Outcomes of preterm infants treated with hypothermia for hypoxic-ischemic encephalopathy

Early Human Development
Tamara I HerreraMargarita Bidegain

Abstract

Therapeutic hypothermia reduces the risk of death, or moderate to severe neurodevelopmental impairment (NDI) in term infants with hypoxic-ischemic encephalopathy (HIE). Reports of its safety and efficacy in preterm infants are scarce. Report short and long-term outcomes of preterm infants with HIE who received therapeutic hypothermia. A retrospective cohort analysis of all preterm infants <36 weeks' gestation with HIE who received whole body hypothermia in a single center from January 2007 to April 2015. The primary outcome was death or moderate to severe NDI defined by moderate or severe cerebral palsy, severe hearing or visual impairment, or cognitive score < 85 on the Bayley Scales of Infant Development III (BSID III) at 18-24 months' adjusted age. 30 infants with a median gestational age and birthweight of 35 weeks' (range; 33-35) and 2575 g (1850-4840) and a median first postnatal blood pH of 6.81 (6.58-7.14). Complications included coagulopathy (50%), early clinical seizures (43.3%), arterial hypotension (40%), persistent metabolic acidosis (37%) and thrombocytopenia (20%). Four infants died before or soon after discharge (18.2%). Eighteen surviving infants (69.2%) had follow up data; 7 of them had moderate to severe NDI ...Continue Reading

Citations

Aug 23, 2019·Acta Paediatrica·Stamatios GiannakisUNKNOWN German Neonatal Hypothermia Network
May 5, 2018·Beneficial Microbes·A F AthiyyahS M Sudarmo
Jun 26, 2020·Frontiers in Cellular Neuroscience·Juan Carlos FernándezAlfredo Martínez
Nov 12, 2020·Expert Review of Neurotherapeutics·Francesco PisaniCarlotta Spagnoli
Nov 4, 2020·Journal of Perinatal Medicine·Katherine CarltonSusan S Cohen
Jan 30, 2021·Therapeutic Hypothermia and Temperature Management·Barbara MichniewiczDawid Szpecht
Oct 12, 2020·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Lavanya RavichandranChristy G Woolcott
Feb 11, 2021·International Journal of Molecular Sciences·Nathanael YatesJoanne O Davidson
Mar 10, 2021·Archives of Disease in Childhood. Fetal and Neonatal Edition·Lara ShipleyDon Sharkey
Sep 30, 2020·Neurología : publicación oficial de la Sociedad Española de Neurología·A Garcia-AlixUNKNOWN Grupo Cerebro Neonatal
Apr 27, 2021·Frontiers in Pharmacology·Manuel Rey-FunesAlfredo Martínez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Pediatrics
Ira Adams-ChapmanFollow-Up Study of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Net
The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Farmeschi LauraGiuseppe Buonocore
© 2022 Meta ULC. All rights reserved