PMID: 21959503Oct 1, 2011

Outcomes of renal transplantation in recipients with peak panel reactive antibody >30% under tacrolimus-based immunosuppression

Annals of Transplantation : Quarterly of the Polish Transplantation Society
Amit BasuRon Shapiro

Abstract

Renal transplant recipients with high panel reactive antibodies (PRA) have worse outcomes than those with lower PRA. High PRA re-transplant recipients are thought to have worse outcomes than high PRA first transplant recipients. In this study, we examined outcomes of renal transplantation recipients with a peak PRA >30% and compared the outcomes of first and re-transplanted recipients. Survival outcomes between recipients of first transplants (n=68) and re-transplants (n=155) operated between June 1990 and August 2000 were compared. Sub-group analysis was done based on patient's gender, race and first/re-transplant. All patients received tacrolimus-based immunosuppression. No difference in graft survival was noted between first and re-transplanted patients. Ten-year patient survival was better in the re-transplanted group (p<0.004). Factors affecting patient survival on univariate analysis were age >55 years (p=0.015), deceased donor transplant (p=0.009), first transplant patient (p=0.004) and diabetes mellitus (DM) as the cause of End Stage Renal Disease (ESRD) (p=0.005). On multivariable analysis, factors affecting patient survival were number of the transplant (re-transplant versus first transplant, Relative risk [RR]=0.54, ...Continue Reading

References

Feb 3, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Lu HuberKlemens Budde
Apr 16, 2018·Clinical Transplantation·David D AufhauserMatthew H Levine

Related Concepts

Kidney Failure
Kaplan-Meier Estimate
Graft Survival
Isoantibodies
Kidney
Tacrolimus
Nodular Glomerulosclerosis
Kidney Failure, Chronic
Multivariate Analysis
Adjustment Disorders

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