Outcomes of single-centre experience of hepatic resection and cryoablation of sarcoma liver metastases

American Journal of Clinical Oncology
Terence C ChuaDavid L Morris

Abstract

Liver metastasis from sarcoma in metastatic disease is common and its effect on prognosis remains ill defined. Surgery remains paramount in sarcoma management; however, there is inadequate literature reporting the role of hepatic surgery as treatment for sarcoma liver metastases. Fifteen patients who underwent hepatic resection for metastatic sarcoma between January 1, 1995 and January 1, 2009 were identified from a prospective hepatobiliary database. Clinicopathologic, operative, recurrence, and long-term survival data are presented. Three patients had synchronous liver metastases. The median time to developing liver metastasis was 26 (range, 0-206) months. The overall median survival from hepatic resection of liver metastasis was 103 (95% confidence interval, 6-200) months with a 5- and 10-year survival of 51% and 37%, respectively. The median disease-free survival from hepatic resection was 14 (95% confidence interval, 11-18) months. CD117 positive tumors was associated with an improved survival with a 3-year survival of 80% compared with 33% in CD117 negative tumors (P = 0.02). Hepatic resection for sarcoma liver metastases with or without extrahepatic disease is a reasonable management strategy if a complete resection may ...Continue Reading

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Citations

Aug 26, 2014·Langenbeck's Archives of Surgery·Timothy L FitzgeraldEmmanuel E Zervos
Nov 20, 2016·Journal of Oncology Practice·Paul H SugarbakerMary Hesdorffer
May 30, 2013·American Society of Clinical Oncology Educational Book·Peter HohenbergerKamran Ahrar

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