Nov 30, 2019

Outcomes of Systemic Lupus Erythematosus in Patients who Discontinue Hydroxychloroquine

ACR Open Rheumatology
Z AouhabR A Ostrowski

Abstract

Hydroxychloroquine (HCQ) is an antimalarial drug that is recommended as a safe, daily prophylactic intervention for individuals with systemic lupus erythematosus (SLE) based on previous studies that showed an association of HCQ use with reductions in flares compared with placebo. Our study aims to determine whether the discontinuation of HCQ leads to relapse of disease and whether the duration of HCQ use impacts the success of its eventual discontinuation. A retrospective chart review was performed on the medical records of patients diagnosed with SLE between July 1, 2006, and June 30, 2016. The data gathered included demographic factors, diagnostic symptoms, laboratory values, and SLE medications. Additionally, HCQ usage and discontinuation rates were collected as well as the timing and prevalence of flares during and after HCQ usage. Patients who were diagnosed with SLE but never used HCQ were excluded from the study. The occurrence of flares, clinical characteristics, and duration of treatment with HCQ were compared between the group that continued HCQ and the group that discontinued HCQ. Of the 509 patients who met inclusion criteria, 66.2% (n = 337) continued HCQ throughout the duration of their treatment (median duration ...Continue Reading

  • References
  • Citations2

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations2

Mentioned in this Paper

Study
Thrombocytopenia
Hydroxychloroquine
Laboratory
Leukopenia
Arthritis
Pharmaceutical Preparations
Lupus Erythematosus, Systemic
Discontinuation (Procedure)
Retrospective Studies

Related Feeds

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.