Outcomes of the addition of pasireotide to traditional adrenal-directed treatment for dogs with pituitary-dependent hyperadrenocorticism secondary to macroadenoma: 9 cases (2013-2015)

Journal of the American Veterinary Medical Association
Maya Lottati, D Bruyette

Abstract

OBJECTIVE To evaluate clinical signs, endocrine test results, and pituitary tumor size for dogs with medically managed pituitary-dependent hyperadrenocorticism (PDH) and macroadenoma following 6 months of concurrent treatment with pasireotide. DESIGN Prospective case series. ANIMALS 9 client-owned dogs with PDH and macroadenoma in which PDH had been successfully managed with adrenal-directed treatment (trilostane or mitotane). PROCEDURES Dogs were given pasireotide (0.03 mg/kg [0.014 mg/lb], SC, q 12 h) for 6 months, while adrenal-directed treatment was continued. Physical examination, basic clinicopathologic testing, ACTH stimulation testing, and plasma ACTH concentration measurement were performed before (baseline) and 3 and 6 months after treatment began. Measurements of pituitary gland volume and pituitary gland-to-brain ratio were performed via MRI at baseline and 6 months after treatment began. RESULTS No dog developed neurologic abnormalities or signs of adverse effects during the study period. No differences from baseline were identified in clinicopathologic values, ACTH stimulation test results, or plasma ACTH concentration at the 3- or 6-month assessment points. After 6 months of pasireotide treatment, 6 dogs had decr...Continue Reading

References

Dec 1, 1990·The Journal of Clinical Endocrinology and Metabolism·V HermanS Melmed
Apr 16, 1999·Endocrine Reviews·P L Dahia, A B Grossman
Mar 16, 2001·Expert Opinion on Pharmacotherapy·A ColaoL Annunziato
Nov 15, 2002·Molecular and Cellular Endocrinology·S W J Lamberts
Nov 15, 2002·Molecular and Cellular Endocrinology·Roselinda H van der Vlugt-MeijerBjörn P Meij
May 24, 2003·Frontiers in Neuroendocrinology·Andy Levy, Stafford Lightman
Jul 24, 1958·The New England Journal of Medicine·D H NELSONG W THORN
May 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Rosario PivonelloSteven W J Lamberts
Nov 29, 2005·Endocrine·Maria A TichomirowaAlbert Beckers
Feb 16, 2006·Current Gene Therapy·Claudia B HereñúRodolfo G Goya
Oct 26, 2006·The Journal of Clinical Endocrinology and Metabolism·Guillaume AssiéXavier Bertagna
Nov 3, 2006·American Journal of Veterinary Research·Roselinda H van der Vlugt-MeijerGeorge Voorhout
Sep 8, 2009·Research in Veterinary Science·V A Castillo, M F Gallelli
Mar 9, 2012·The New England Journal of Medicine·Annamaria ColaoUNKNOWN Pasireotide B2305 Study Group
Oct 12, 2013·Journal of Veterinary Internal Medicine·E N BehrendJ C Scott-Moncrieff
Jan 16, 2014·The Journal of Clinical Endocrinology and Metabolism·A ColaoUNKNOWN Pasireotide C2305 Study Group
Mar 4, 2015·Endocrinology and Metabolism Clinics of North America·Maria Fleseriu
Apr 30, 2016·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·L TrementinoG Arnaldi

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Citations

Feb 19, 2021·World Neurosurgery·Emma De RavinJohn Y K Lee
Mar 2, 2021·The Veterinary Journal·K SandersB P Meij

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