Outcomes of the Boston Type I Keratoprosthesis as the Primary Penetrating Corneal Procedure

Cornea
Todd H DriverAnthony J Aldave

Abstract

To report the outcomes of the Boston type I keratoprosthesis (KPro) as the primary penetrating corneal procedure. In this retrospective review of all KPro procedures performed by 2 surgeons from May 1, 2004, to December 31, 2015, indications and outcomes were compared between KPros performed as the primary keratoplasty procedure (primary KPro) versus after failed keratoplasty (previous keratoplasty). A total of 262 KPros were implanted in 231 eyes, including 67 primary KPro procedures. The most common indications for primary KPros were corneal scarring/vascularization (43%), Stevens-Johnson syndrome (22%), and chemical/thermal injury (22%). Although preoperative corrected distance visual acuity (CDVA) was similar in the 2 groups (P = 0.36), a significantly higher proportion of the eyes in the primary KPro group had a CDVA ≥ 20/200 each of the first 4 years after surgery (all P ≤ 0.023). The most common postoperative complications in the primary KPro and previous keratoplasty groups were retroprosthetic membrane (40% vs. 51%, P = 0.15), persistent epithelial defect (37% vs. 24%, P = 0.05), and elevated intraocular pressure, which was the only complication significantly more common in either group (31% vs. 18%, P = 0.03). No diff...Continue Reading

References

Apr 1, 1995·Ophthalmology·I Tugal-TutkunC S Foster
May 30, 2002·The British Journal of Ophthalmology·M HalberstadtJ G Garweg
Jul 18, 2003·Ophthalmology·Robert W ThompsonFrancis W Price
Apr 25, 2006·Cornea·Alexandre Menezes de FreitasFlávio Jaime Rocha
Apr 24, 2007·International Ophthalmology Clinics·Bilal F KhanClaes H Dohlman
Jun 5, 2007·American Journal of Ophthalmology·Esen Karamursel AkpekClaes H Dohlman
Jun 15, 2007·Archives of Ophthalmology·Bilal F KhanClaes H Dohlman
Sep 26, 2007·Cornea·Mohammad Ali JavadiHossein Mohammad Rabei
Jan 22, 2008·American Journal of Ophthalmology·Rony R SayeghClaes H Dohlman
May 4, 2011·Current Opinion in Ophthalmology·Kathryn A Colby, Euna B Koo
Mar 2, 2013·Cornea·Jordan J RixenKenneth M Goins
Jan 4, 2015·American Journal of Ophthalmology·Sumayya AhmadPradeep Y Ramulu
Jun 3, 2015·The British Journal of Ophthalmology·Raphaëlle FadousMona Harissi-Dagher
Apr 15, 2016·Cornea·Borja Salvador-CullaMiguel A López
Apr 6, 2017·Arquivos brasileiros de oftalmologia·Yesim AltayFirdevs Ornek
May 13, 2017·The British Journal of Ophthalmology·Melinda FryAnthony J Aldave

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Citations

Apr 30, 2019·Current Opinion in Ophthalmology·Priyanka Chhadva, Maria S Cortina
Mar 7, 2020·European Journal of Ophthalmology·Marta Jerez-PeñaRafael I Barraquer
May 20, 2020·Clinical Ophthalmology·Manachai NonpassoponMaria Soledad Cortina
Jun 20, 2020·The British Journal of Ophthalmology·Swapna S ShanbhagSayan Basu
Feb 25, 2021·The British Journal of Ophthalmology·Taylor NaymanMona Harissi-Dagher
Mar 5, 2021·The British Journal of Ophthalmology·Jonathan El-KhouryMona Harissi-Dagher
Mar 18, 2021·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·F SchaubC Cursiefen
Apr 27, 2021·Seminars in Ophthalmology·Priyanshi AwasthiAmit Raj
May 12, 2021·Current Opinion in Ophthalmology·Ellen H Koo, Sadeer B Hannush
Feb 26, 2021·Cornea·Reza GhaffariAnthony J Aldave

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