Outcomes of thoracoscopic thymectomy in patients with juvenile myasthenia gravis

Journal of Pediatric Surgery
Awais AshfaqDavid M Notrica

Abstract

Myasthenia gravis (MG) is an autoimmune disorder of the postsynaptic neuromuscular junction resulting in fatigability of voluntary muscles. There has been increasing evidence supporting thymectomy for MG in adults, and evidence for the role of surgery in pediatric age groups is increasing. The purpose of this study is to describe the outcomes of our patients with juvenile MG undergoing thoracoscopic thymectomy. All patients with juvenile MG who underwent thoracoscopic thymectomy at Phoenix Children's Hospital between 1999 and 2014 were included. Patients were diagnosed by their treating neurologist. An Osserman and Genkins criterion was used to classify the severity of the disease and DeFilippi classification was used to assess remission. Twelve patients underwent thoracoscopic thymectomy for juvenile MG during the time frame studied. Nine (75%) patients had an Osserman stage of IIB, with only two patients with ocular disease. There were no conversions to an open procedure. Seven (59%) patients had normal thymic histology, 4 (33%) had evidence of follicular hyperplasia and one (8%) had involutional changes. The median length of hospital stay was 2days (range 1-5days). There was no 30-day postoperative morbidity, reoperations or...Continue Reading

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Citations

Dec 29, 2016·The New England Journal of Medicine·Nils E Gilhus
Apr 13, 2017·Pediatric Surgery International·Arin L MadenciChristopher B Weldon
Feb 8, 2019·Pediatric Surgery International·Aimee G KimThane A Blinman
May 24, 2019·Pediatric Surgery International·Michael A CatalanoRichard D Glick
Sep 29, 2019·Current Treatment Options in Neurology·Kristen Fisher, Veeral Shah
Jan 23, 2021·The Annals of Thoracic Surgery·Zhongmin LiJens-C Rueckert

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