PMID: 11914163Mar 27, 2002Paper

Outcomes research in the development and evaluation of practice guidelines

BMC Health Services Research
Louise Pilote, Ira B Tager

Abstract

Practice guidelines have been developed in response to the observation that variations exist in clinical medicine that are not related to variations in the clinical presentation and severity of the disease. Despite their widespread use, however, practice guideline evaluation lacks a rigorous scientific methodology to support its development and application. Firstly, we review the major epidemiological foundations of practice guideline development. Secondly, we propose a chronic disease epidemiological model in which practice patterns are viewed as the exposure and outcomes of interest such as quality or cost are viewed as the disease. Sources of selection, information, confounding and temporal trend bias are identified and discussed. The proposed methodological framework for outcomes research to evaluate practice guidelines reflects the selection, information and confounding biases inherent in its observational nature which must be accounted for in both the design and the analysis phases of any outcomes research study.

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Citations

Feb 1, 2006·Expert Review of Pharmacoeconomics & Outcomes Research·Kent H Summers, Nalin Payakachat
Aug 14, 2002·BMC Musculoskeletal Disorders·A CranneyD S Ooi
Apr 20, 2006·Journal of the American Medical Informatics Association : JAMIA·Joyce C NilandDouglas C Stahl
Oct 31, 2013·SpringerPlus·Jatin ShahNilima Kshirsagar
Dec 4, 2003·Journal of Cardiopulmonary Rehabilitation·Randal J Thomas
Dec 25, 2007·Advances in Chronic Kidney Disease·Sandeep SomanJerry Yee

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