Outcomes With Age Combinations in Living Donor Kidney Transplantation

The American Surgeon
Sadaf AslamJames Huang

Abstract

Reevaluation of donor criteria, including age, is needed to combat organ shortages, lengthy wait times, and anticipated recipient mortality rates. The purpose of this study was to evaluate donor and recipient (D/R) age combinations and patient and graft survival outcomes. Single-organ, living donor kidney transplantations (LDKTs) from 2012 to 2018 were retrospectively reviewed. Donors and recipients were placed into "older" and "younger" age categories of 50 years and above or below age 50, then analyzed with SPSS version 25. We performed 347 LDKTs. Younger-to-older pairings had significantly higher rates of smoking in recipient (53.6%) and hepatitis C (5.5%), but shorter hospital stays (5.3 days). Older-to-younger pairings had the longest hospital stays (7.4 days) but the shortest cold ischemic time (2.3 hours). Notably, there was no significant variance in delayed graft function (first-week dialysis) between groups. Regarding complication rates, only bleeding within 30 days, highest in older-to-older pairings (7.7%), and renal complications, highest in older-to-younger pairings, significantly varied between groups. Interestingly, though younger-to-older cases had the longest mean graft survival time, older kidneys lasted 537 ...Continue Reading

References

Jan 25, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Adina VoiculescuBernd Grabensee
Jul 23, 2008·Transplantation·Robert C MinneeMirza M Idu
Sep 20, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Massimiliano VerouxPierfrancesco Veroux
Oct 29, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Jonathan C BergerDorry L Segev
Aug 16, 2015·Clinical Journal of the American Society of Nephrology : CJASN·James R RodrigueUNKNOWN American Society of Transplantation
Jun 10, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Valarie B AshbyJohn D Kalbfleisch

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