Outer membrane proteins responsible for the penetration of beta-lactams and quinolones in Pseudomonas aeruginosa

The Journal of Antimicrobial Chemotherapy
Y YamanoY Komatsu

Abstract

Porin-deficient mutants of Pseudomonas aeruginosa PAO1 were selected by isolating latamoxef-resistant mutants following chemical mutagenesis. Highly latamoxef-resistant mutants had alterations in both the outer membrane proteins and penicillin-binding protein 3, a lethal target of latamoxef. Both of these alterations may be essential for cells to acquire high resistance to latamoxef. Many of the latamoxef-resistant mutants were also resistant to new quinolones and chloramphenicol. Resistance to these compounds was simultaneously co-transduced from one mutant into strain PAO1 when selection was made for transduction of ofloxacin resistance. Study of these transductants indicated that decreased amounts of outer membrane proteins C, D2, E1, and E2 lowered the outer membrane permeability and resulted in resistance. Three of these proteins were apparently identical to proteins previously reported to function as small pores. The results suggested that at least one of the four proteins was functioning as a porin for the antibacterial agents studied.

Citations

Jun 9, 2005·Advanced Drug Delivery Reviews·Ayush Kumar, Herbert P Schweizer
Jan 1, 1993·The Journal of Applied Bacteriology·V S Brözel, T E Cloete
Jun 1, 1994·The Journal of Applied Bacteriology·V S Brözel, T E Cloete
Oct 1, 1991·Antimicrobial Agents and Chemotherapy·M Michéa-HamzehpourJ C Pechère
Aug 1, 1992·Antimicrobial Agents and Chemotherapy·C McCaffreyN H Georgopapadakou
Sep 1, 1992·Antimicrobial Agents and Chemotherapy·C R CatchpoleJ M Andrews
Dec 11, 2003·Microbiology and Molecular Biology Reviews : MMBR·Hiroshi Nikaido
Jun 21, 2005·Infectious Disease Clinics of North America·Khalil G GhanemJonathan M Zenilman
Aug 1, 1996·Antimicrobial Agents and Chemotherapy·T KocagözH F Chambers
Jun 26, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Moustafa A Tag ElDeinMona T Kashef
Jan 1, 1996·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Isamu SaikawaYasuo Watanabe
Jul 25, 2018·ACS Infectious Diseases·Susruta SamantaMatteo Ceccarelli

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