Outer retina changes on optical coherence tomography in vitamin A deficiency

International Journal of Retina and Vitreous
Meghan K BerkenstockAndrew R Carey

Abstract

Vitamin A deficiency is rare in the United States and can be missed in patients with malabsorption syndromes without a high dose of suspicion. Ocular complications of hypovitaminosis A include xerosis and nyctalopia, and to a lesser extent reduction in visual acuity and color vision. Outer retinal changes, as seen on spectral domain optic coherence tomography (SD-OCT), in patients with vitamin A deficiency have previously not been documented. We present two cases with symptoms of severe nyctalopia who were subsequently diagnosed with severe Vitamin A deficiency and their unique findings on SD-OCT of outer nuclear layer diffuse thinning with irregular appearance of the interdigitating zone and the ellipsoid zone as well as normalization after vitamin A supplementation. Outer nuclear layer thinning and disruption of the outer retinal bands on SD-OCT are reversible with correction of vitamin A deficiency. Improvement in visual acuity, color vision, and nyctalopia are possible with early diagnosis and appropriate treatment.

References

Jun 13, 1998·American Journal of Ophthalmology·G PanozzoA Bonora
May 12, 2005·Ophthalmology·W Barry LeeIvan R Schwab
May 18, 2006·Klinische Monatsblätter für Augenheilkunde·E PitchonF-X Borruat
Oct 8, 2009·Documenta Ophthalmologica. Advances in Ophthalmology·Mohamed A GeneadMartin Lindeman
Oct 23, 2009·Obesity Surgery·Christine StrohThomas Manger
Nov 6, 2010·Alimentary Pharmacology & Therapeutics·H-B FiebrichE G E De Vries
Sep 27, 2012·Eating and Weight Disorders : EWD·J S FokT Y Yong
Aug 1, 2013·Documenta Ophthalmologica. Advances in Ophthalmology·Tomas S AlemanAlexander J Brucker
Dec 10, 2013·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Takashi NishidaKazuyoshi Hayakawa
Jan 15, 2016·American Journal of Surgery·Sohaib KhanJorge Ortiz
Jan 20, 2016·Cornea·Sidney M GospeMelissa Daluvoy
Nov 21, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Jacqueline Souza SilvaAndréa Ramalho
Jan 27, 2018·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Wayne J EnglishJohn M Morton
Mar 9, 2018·Case Reports in Ophthalmology·Amanda R CrumFasika Woreta
Nov 19, 2018·Clinics in Plastic Surgery·Sanja Sljivic, Jeffrey A Gusenoff
Jun 17, 2019·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Lisa M JohnsonAnthony A Killeen
Jul 10, 2019·Pediatric Blood & Cancer·Miriam B G MorrellKaren Moody

❮ Previous
Next ❯

Citations

Jun 23, 2021·European Journal of Ophthalmology·Lidia Remolí SarguesEnrique Cervera Taulet

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Optometry and Vision Science : Official Publication of the American Academy of Optometry
Anne LeeDavid Mietzner
Documenta Ophthalmologica. Advances in Ophthalmology
Tomas S AlemanAlexander J Brucker
Nihon rinsho. Japanese journal of clinical medicine
N Hashizume
Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
R L LesserS L Sugin
© 2022 Meta ULC. All rights reserved