PMID: 11931075Apr 5, 2002Paper

Outflow facilities through Descemet's membrane in rabbits

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Detlev SpiegelK Kobuch

Abstract

The outflow pathway in viscocanalostomy, a new procedure in glaucoma surgery, is unclear; however, outflow through Descemet's membrane has been postulated. This study evaluates outflow rates through Descemet's membrane at different IOP levels in rabbits. 51 Descemet's membranes without endothelium from enucleated rabbit eyes were installed in a double-ring system, the Minuth sheet. Different intraocular pressure levels (20, 25, 30, 40, 50 mmHg) were applied to one side of the system. The system was filled with balanced salt solution. The total amount of fluid percolating through Descemet's membrane was measured after 12 h. Based on this, flow rates were calculated. The area of Descemet's membrane was 6.9 mm2. At the pressure of 20 mmHg the flow rate was less than 0.003 microl/min. At pressures above 30 mmHg flow rates ranged from 0.04 microl/min to 0.15 microl/min with a mean of 0.09 microl/min. To achieve pressure control at high pressures, an area of at least 150 mm2 of Descemet's membrane would be needed. Descemet's membrane provides good outflow resistance in rabbit eyes. Based on our results for pressure control by outflow through Descemet's membrane only, at least the whole corneal area is needed. If the same is true in h...Continue Reading

Citations

May 30, 2009·International Ophthalmology·Mehmet Numan AlpGulcan Kural
Feb 2, 2013·Clinical and Translational Medicine·Will W Minuth, Lucia Denk
Oct 12, 2012·Clinical Ophthalmology·Karim Mohamed-Noriega, Jodhbir S Mehta
Jan 26, 2010·Biomaterials·Will W MinuthAnne Glashauser
Jun 5, 2004·Journal of Cataract and Refractive Surgery·Tarek ShaarawyAndré Mermoud
Sep 22, 2006·Journal of Glaucoma·Jianbo Zhou, Gregory T Smedley
Feb 28, 2008·Journal of Glaucoma·Fernando Galassi, Barbara Giambene
Apr 28, 2009·European Journal of Ophthalmology·Mehmet Baykara, Ozgur Timucin

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