Outpatient Antibiotic Stewardship: A Growing Frontier-Combining Myxovirus Resistance Protein A With Other Biomarkers to Improve Antibiotic Use

Open Forum Infectious Diseases
Patrick Joseph, Eliot Godofsky

Abstract

The majority of oral antibiotics are prescribed in outpatient primary and urgent care clinics for acute respiratory infections. Effective antibiotic stewardship must include proper prescribing for outpatients as well as for those in a hospital or long-term care facility. Major databases, including MEDLINE and the Cochrane Library, were searched for prospective human clinical studies, including children and/or adults published between January 1966 and November 2017 that evaluated Myxovirus resistance protein A (MxA) as a biomarker for diagnosing viral infections as well as both C-reactive protein (CRP) and procalcitonin (PCT) as potential biomarkers for identifying and differentiating true bacterial upper respiratory infection (URI) from colonization. Ten prospective human studies, totaling 1683 patients, were identified that evaluated MxA as a viral biomarker in children and/or adults. Both systematic review articles, meta-analyses, and randomized controlled clinical trials that examined CRP and/or PCT as a biomarker for identifying clinically significant bacterial infections and supporting antibiotic stewardship were identified. Quick and accurate differentiation between a viral and bacterial respiratory infection is critical ...Continue Reading

References

Jun 1, 1977·Arthritis and Rheumatism·S HonigG Weissmann
May 1, 1988·American Journal of Diseases of Children·M A GerberD R Mayo
Jan 1, 1986·Archives of Disease in Childhood·A PuttoP Halonen
Mar 1, 1983·Pediatric Infectious Disease·L A HansonC Wadsworth
Jan 1, 1993·Advances in Virus Research·G C Sen, R M Ransohoff
Dec 1, 1994·The Journal of Clinical Endocrinology and Metabolism·P DandonaC Bohuon
Jan 1, 1994·The Pediatric Infectious Disease Journal·S T Shulman
Apr 30, 1998·Journal of Virological Methods·V ChieuxP Wattré
Jul 29, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H M El-SahlyS B Greenberg
Feb 15, 2001·The New England Journal of Medicine·A L Bisno
Jun 1, 2001·Annals of Emergency Medicine·R J CooperUNKNOWN Centers for Disease Control and Prevention
Jun 28, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Catherine ChirouzeBruno Hoen
Apr 2, 2003·Annals of Internal Medicine·Michael A SteinmanC Seth Landefeld
Jun 5, 2003·Pharmacology & Therapeutics·Santo LandolfoDavid Lembo
Jul 16, 2003·Annals of Internal Medicine·Joan M NeunerMark D Aronson
Apr 1, 1960·Circulation·L W WANNAMAKER, E M AYOUB
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Liliana SimonJacques Lacroix
Feb 8, 2006·The Pediatric Infectious Disease Journal·Mohamed ElsammakMona Kandil
Apr 11, 2006·American Journal of Respiratory and Critical Care Medicine·Mirjam Christ-CrainBeat Müller
Oct 27, 2006·Pediatric Research·Motokazu NakabayashiToshio Miyawaki
Jun 12, 2008·The Journal of Infectious Diseases·Susan E HooverJeffrey I Cohen
Oct 15, 2008·Archives of Internal Medicine·Matthias BrielMirjam Christ-Crain
Feb 27, 2010·The European Respiratory Journal·O BurkhardtT Welte
Apr 28, 2010·Journal of Clinical Microbiology·David N Gilbert
Aug 28, 2012·American Journal of Respiratory and Critical Care Medicine·Carl LlorMarc Miravitlles
Nov 15, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Angela M CaliendoUNKNOWN Infectious Diseases Society of America (IDSA)
Nov 26, 2013·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Yafang HuangAimin Guo
Mar 13, 2014·Scandinavian Journal of Infectious Diseases·Ann Marlene Gram ChristensenTejs Ehlers Klug
May 9, 2014·Journal of the American Board of Family Medicine : JABFM·Olga CalviñoSilvia Hernández

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Citations

Sep 2, 2019·Current Infectious Disease Reports·Kelli A ColeLisa E Dumkow
Oct 2, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Akelew YibeltalCnops Lieselotte
May 21, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Henry C CarltonMartha M C Elwenspoek

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