PMID: 28525232Jan 1, 2016Paper

Outpatient management of community acquired meticillin resistant Staphylococcus aureus (MRSA) in Belgium

Revue médicale de Bruxelles
M Gerard

Abstract

Meticillin resistance is observed among S.aureus strains since 1961 and is due to the synthesis by S.aureus of a modified penicillin binding proteins named PBP2a with decreased affinity to Meticillin. Meticillin-resistant S.aureus (MRSA) strains are resistant to all betalactam antibiotics except Ceftaroline. Three epidemiological type of MRSA are now described globally in Europe and certainly in Belgium. These different types of MRSA differ by their genetic composition, the presence of virulence factors, their transmissibility, their clinical picture and their sensitivity to ant ibiot ics. The first one are the hospi tal associated MRSA strains (HA-MRSA) that causes pneumonia, urinary tract infection or bacteremia mostly among old patients presenting multiple comorbidities. Multiresistance to antibiotics is frequent in HA-MRSA and treatment of HA-MRSA related infections usually necessitate hospitalization of the patient. The second type of MRSA is a livestock associated MRSA (LA-MRSA). At risk persons are person living in close contact to livestock as farmers and veterinarians). The third type of MRSA is the community associated MRSA (CA-MRSA) described among individuals with little or no exposure to healthcare facilities. CAMR...Continue Reading

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