Outpatient parenteral antibiotic therapy in a suburban tertiary referral centre in Australia over 10 years

Infection
Wenlong LiArchana Sud

Abstract

Outpatient parenteral antibiotic therapy (OPAT) is a widely accepted and safe therapeutic option for carefully selected patients. This study reviewed the practice of an OPAT service in a large Australian tertiary teaching hospital in Western Sydney over a 10-year period. Data were retrieved from a prospectively maintained electronic database which included information on patient demographics, clinical diagnosis, microbiological identity, antimicrobial therapy, complications and readmissions. Data were analysed using descriptive statistics. There were 3435 referrals made to the service between January 2004 and June 2014, amounting to 25,289 antibiotic days. The most frequent referral was for Skin and Soft Tissue Infections (SSTIs), 61.28%, followed by Bone and Joint Infections (BJIs), 15.30%. The most common organism identified was methicillin-sensitive Staphylococcus aureus. Readmission was uncommon (5.15%), with the highest rate of readmission noted for Cardiovascular System Infections (16.67%) followed by BJIs (10.31%). Line infection, aseptic thrombophlebitis and drug hypersensitivity or reaction were the cause of 68.55% of all complications. There was a decline in line-related complications throughout the study period. OPAT...Continue Reading

References

Jun 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M M Andrews, C F von Reyn
Apr 2, 2003·The Journal of Antimicrobial Chemotherapy·Alan D TiceDavid A Shoultz
Sep 29, 2005·Emergency Medicine Journal : EMJ·M DonaldM Wu
Sep 14, 2007·Scandinavian Journal of Infectious Diseases·James H McMahonM Lindsay Grayson
Sep 25, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Paul R IngramJohn R Dyer
Sep 27, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C PulciniP-M Roger
Oct 10, 2008·The Journal of Antimicrobial Chemotherapy·Anthony R White, UNKNOWN BSAC Working Parties on Resistance Surveillance
Apr 22, 2009·Clinical Orthopaedics and Related Research·Anurag DuggalSteven K Schmitt
Aug 22, 2009·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J KieranC Bergin
Sep 3, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph A Paladino, Donald Poretz
Nov 6, 2012·The Medical Journal of Australia·Gideon A CaplanLouise Barclay
Nov 10, 2013·International Journal of Antimicrobial Agents·Michael MacKenzieDilip Nathwani
Jun 10, 2014·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Jennifer MoranSantosh Reddy
Jan 13, 2015·The Cochrane Database of Systematic Reviews·Patrick BrassAndrew F Smith
Jan 13, 2015·The Cochrane Database of Systematic Reviews·Patrick BrassAndrew F Smith
Jan 22, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·S SubediE G Playford
Sep 16, 2015·Annals of Internal Medicine·Vineet ChopraUNKNOWN Michigan Appropriateness Guide for Intravenouse Catheters (MAGIC) Panel
May 12, 2016·Archives of Disease in Childhood·Kate A HodgsonPenelope A Bryant

❮ Previous
Next ❯

Citations

May 5, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Eleanor D SadlerSara C Keller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.