Outpatient parenteral antibiotic therapy with daptomycin: insights from a patient registry.

International Journal of Clinical Practice
W J MartoneDavid E Katz

Abstract

To compare and contrast the characteristics and clinical outcomes of patients who have received daptomycin as outpatients and inpatients. The Cubicin Outcomes Registry and Experience (CORE) is a retrospective chart review of patients who have received daptomycin in participating institutions. Patients treated in 2005 were included in this analysis. Demographic characteristics and clinical outcomes (success = cured + improved) were compared among patients who received outpatient parenteral antibiotic therapy (OPAT) and patients who had received inpatient parenteral antibiotic therapy (IPAT). Of 1172 patients reported by 52 CORE 2005 participating institutions/investigators, 949 (81.0%) patients were evaluable: 539 (56.8%) received OPAT (OPAT patients), and 410 (43.2%) received only IPAT (IPAT patients). Of the 539 OPAT patients, 273 (50.6%) also received some IPAT, usually preceding OPAT therapy. Successful outcomes [no. of successes/(no. of successes + no. of failures)] for OPAT patients vs. IPAT patients were 94.6% and 86.3% respectively (chi-square test, p < 0.001). OPAT patients were younger, had fewer underlying diseases, were clinically stable, and had fewer adverse events than IPAT patients. Outpatient parenteral antibiot...Continue Reading

References

Jan 1, 1993·The American Journal of Medicine·J M ColfordR A Jacobs
Nov 14, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D N WilliamsW A Craig
Jan 15, 1999·Infectious Disease Clinics of North America·D M Poretz
Jan 15, 1999·Infectious Disease Clinics of North America·D Andes, W A Craig
Jan 15, 1999·Infectious Disease Clinics of North America·S J Rehm
Jan 15, 1999·Infectious Disease Clinics of North America·A D Tice
Jan 15, 1999·Infectious Disease Clinics of North America·H G Deery
Feb 28, 2002·The Journal of Antimicrobial Chemotherapy·Peter C FuchsSteven D Brown
Dec 25, 2003·Antimicrobial Agents and Chemotherapy·Nasia SafdarW A Craig
Jul 1, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alan D TiceUNKNOWN IDSA
Jul 1, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert D ArbeitUNKNOWN Daptomycin 98-01 and 99-01 Investigators
Feb 12, 2005·The Journal of Antimicrobial Chemotherapy·Judith N SteenbergenFrancis P Tally
Jul 12, 2005·Southern Medical Journal·Keith M Ramsey, John A Vande Waa
Aug 18, 2006·The New England Journal of Medicine·Vance G FowlerUNKNOWN S. aureus Endocarditis and Bacteremia Study Group

❮ Previous
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Citations

Nov 10, 2013·International Journal of Antimicrobial Agents·Michael MacKenzieDilip Nathwani
Oct 10, 2008·The Journal of Antimicrobial Chemotherapy·R A Seaton
Mar 22, 2013·The Journal of Antimicrobial Chemotherapy·R Andrew SeatonRicardo L Chaves
Oct 12, 2013·Clinical Medicine : Journal of the Royal College of Physicians of London·D A Barr, R A Seaton
Sep 3, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R A SeatonB L Jones
Jun 29, 2011·The American Journal of the Medical Sciences·Julius LariozaRichard B Brown
Jul 5, 2011·Enfermedades infecciosas y microbiología clínica·Carlos CerveraUNKNOWN Hospital Clinic Endocarditis Study Group
Mar 16, 2016·Annals of Clinical Microbiology and Antimicrobials·R Andrew SeatonKamal Hamed
Apr 23, 2013·European Journal of Internal Medicine·R A Seaton, D A Barr
Feb 19, 2010·Expert Opinion on Pharmacotherapy·Christos Kosmidis, Donald P Levine
Mar 12, 2013·International Journal of Antimicrobial Agents·R Andrew SeatonRicardo L Chaves
Mar 23, 2011·International Journal of Antimicrobial Agents·Carlos CerveraJose M Miró
Dec 16, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J-P Stahl
Aug 5, 2016·Journal of Cardiothoracic Surgery·A KornbergerA Beiras-Fernandez
May 18, 2011·Hospital Practice·Peggy S McKinnonAlpesh N Amin
Nov 14, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anne H NorrisCraig A Umscheid

❮ Previous
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