Outpatient Pharmacotherapy for Neonatal Abstinence Syndrome

The Journal of Pediatrics
Faouzi I MaaloufS W Patrick

Abstract

To determine differences in lengths of stay, length of therapy, emergency department (ED) utilization, and hospital readmissions between infants with neonatal abstinence syndrome (NAS) treated exclusively with inpatient pharmacotherapy compared with those discharged on outpatient pharmacotherapy. This retrospective cohort study of infants enrolled in the Tennessee Medicaid program used administrative and vital records data from 2009 to 2011. Medical record review was used to confirm cases of NAS and classify treatment type. Negative binomial regression was used to compare length of therapy and ordinal regression was used to determine frequency of ED visits and hospital readmissions. Among a cohort of 736 patients with confirmed NAS, 72.3% were treated with pharmacotherapy of which approximately one-half (45.5%) were discharged home on outpatient medications. For infants discharged on outpatient pharmacotherapy, initial hospital length of stay was shorter (11 vs 23 days; P < .001) and length of therapy was longer (60 vs 19 days; adjusted incidence rate ratio [aIRR] 2.84, 95%CI 2.31-3.52). After adjusting for potential confounders, infants discharged on outpatient pharmacotherapy had a greater number of ED visits within 6 months ...Continue Reading

Citations

Aug 2, 2019·Hospital Pediatrics·Travis W CrookStephen W Patrick
Nov 24, 2018·Nature Reviews. Disease Primers·Mara G CoyleHendrée E Jones
Jan 14, 2020·Pediatric Annals·Leah Khan
Aug 24, 2021·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Eva M ByerleyJulia D Muzzy Williamson
Dec 4, 2020·Pediatrics·Kathleen M DohertyStephen W Patrick
Feb 27, 2021·Pediatrics·Stephanie L MerharUNKNOWN EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT NEONATAL RESEARCH NETWORK AND THE NIH ENVIRONMENTAL INFLUENCES ON CHILD HEALTH OUTCOMES (ECHO) PROGRAM INSTITUTIONAL DEVELOPMENT AWARDS STATES PEDIATRIC CLINICAL TRIALS NETWORK
Feb 16, 2020·Pediatrics·Susan M LopataStephen W Patrick
Oct 28, 2020·Pediatrics·Stephen W PatrickUNKNOWN COMMITTEE ON FETUS AND NEWBORN, COMMITTEE ON SUBSTANCE USE AND PREVENTION

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