PMID: 3321872Jan 1, 1987Paper

Outpatient treatment of cervical intra-epithelial neoplasia. The CO2 laser versus cryotherapy, a randomized trial

Acta Obstetricia Et Gynecologica Scandinavica
A BergetT Weber

Abstract

In a randomized study, 204 patients were allocated to either laser or cryo treatment for cervical intra-epithelial neoplasia (CIN). The patients were treated on an outpatient basis without anesthesia unless other conditions requiring anesthesia had to be dealt with at the same time. Both the laser and the cryo method were highly acceptable to the patients. Slightly more patients experienced moderate or severe pain during laser treatment, compared with cryo treatment (P = 0.05). Peroperative hemorrhage did not exceed 25 cc except for one laser-treated patient. Postoperative vaginal discharge was more often seen after cryo coagulation, the discharge being malodorous in 36% of cryo-treated patients and in 17% of laser-treated patients. Pelvic inflammatory disease was found in one patient in each treatment group. Postoperative spotting occurred more often in laser-treated patients (49%) than in cryo-treated patients (22%). At follow-up colposcopy 3 months after treatment, the squamocolumnar junction was fully visible significantly more often in laser-treated patients (P less than 0.001). The cure rates after one laser or cryo treatment were 90% and 91%, respectively. Subsequent to 19 initial treatment failures, 8 patients have at p...Continue Reading

Citations

Jun 1, 1993·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P VedelE Bostofte
Jan 21, 2003·Emerging Infectious Diseases·Gillian D Sanders, Al V Taira
Oct 18, 2006·Journal of Lower Genital Tract Disease
Mar 3, 2001·Cancer Treatment and Research·W Robinson
Feb 24, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H YamaguchiS Noda
Dec 5, 2013·The Cochrane Database of Systematic Reviews·Pierre P L Martin-HirschHeather O Dickinson
Aug 31, 2010·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Miriam CremerJuan Felix
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Jan 2, 2003·Obstetrics and Gynecology Clinics of North America·J Thomas Cox
Jan 2, 2003·Obstetrics and Gynecology Clinics of North America·J Thomas Cox

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