Outpatient treatment of juvenile-onset diabetes with a preprogrammed portable subcutaneous insulin infusion system

The American Journal of Medicine
W V TamborlaneP Felig

Abstract

Seven patients with juvenile-onset, insulin-dependent diabetes (aged 13 to 32 years) were continuously treated for 12 to 32 weeks while out of the hospital in their usual environment with a portable, battery-powered infusion pump which delivers insulin subcutaneously in basal (between-meal) doses with pulse dose increments before meals. Mean blood glucose levels (237 +/- 28 mg/dl during conventional insulin therapy) fell to 105 +/- 5 mg/dl after four weeks of pump treatment (p less than 0.01) and were maintained at 80 to 104 mg/dl as pump treatment was continued beyond eight weeks. Glycosylated hemoglobin levels (16.0 +/- 1.5 per cent before pump therapy) also fell within two weeks (p less than 0.01) reaching normal values (9.9 +/- 0.3) after eight weeks of pump therapy. Mean plasma cholesterol and triglyceride levels were elevated during conventional therapy and fell to normal after pump treatment. After the first month of pump treatment, only minor adjustments in insulin dose (less than 5 per cent of total daily dose) were made. No episode of mechanical pump failure occurred during the 1,110 patient-days of treatment. Overinsulinization and underinsulinization due to human error were relatively rare (four and six episodes, re...Continue Reading

References

Jan 28, 1978·British Medical Journal·J C PickupK G Alberti
May 5, 1977·The New England Journal of Medicine·M D SipersteinJ Roth
May 26, 1977·The New England Journal of Medicine·F J Ingelfinger
May 1, 1977·The Journal of Clinical Endocrinology and Metabolism·K H GabbayP M Gallop
Aug 19, 1976·The New England Journal of Medicine·R J KoenigA Cerami
May 9, 1976·The New England Journal of Medicine·G F CahillN Freinkel
May 1, 1974·Diabetes·A M AlbisserR Gander
Feb 18, 1971·The New England Journal of Medicine·L A TrivelliH T Lai
Oct 1, 1968·Clinica Chimica Acta; International Journal of Clinical Chemistry·S Rahbar

❮ Previous
Next ❯

Citations

Apr 1, 1993·Diabetes/metabolism Reviews·S A Amiel
Sep 1, 1983·Diabetologia·J Mirouze
Oct 1, 1985·Acta diabetologica latina·W WaldhäuslH Freyler
Dec 13, 2006·Reviews in Endocrine & Metabolic Disorders·William V TamborlaneStuart A Weinzimer
Sep 1, 1982·The Journal of Pediatrics·M C RudolfW V Tamborlane
Jun 1, 1983·The Journal of Pediatrics·W V Tamborlane, R S Sherwin
Oct 6, 1997·Endocrinology and Metabolism Clinics of North America·C D Saudek
Sep 11, 2001·Journal of the American College of Surgeons·K HanazakiF C Brunicardi
Apr 9, 1981·The New England Journal of Medicine
Aug 9, 1984·The New England Journal of Medicine·UNKNOWN Kroc Collaborative Study Group
Aug 1, 1983·Archives of Disease in Childhood·S A GreeneJ D Baum
Nov 1, 1984·Archives of Disease in Childhood·A G DaviesR J Postlethwaite
Jun 16, 2006·Pediatric Diabetes·William V Tamborlane
Apr 15, 2014·Annals of the New York Academy of Sciences·Thomas PeyserJay S Skyler
Apr 1, 1983·Disease-a-month : DM·M Bergman, P Felig
Oct 1, 1983·The Journal of Pediatrics·A SchiffrinM M Belmonte
Jan 1, 1981·The American Journal of Medicine·J S Soeldner
Aug 30, 2008·The Mount Sinai Journal of Medicine, New York·Jennifer Sherr, William V Tamborlane
Mar 29, 2003·Diabetes Care·Jill Weissberg-BenchellRoopa Seshadri
Jan 1, 1988·The American Journal of the Medical Sciences·D S BellR S Clements
Jun 1, 1987·Acta Paediatrica Japonica; Overseas Edition·Y TsuchiyaN Matsuo
Mar 1, 1987·Diabetic Medicine : a Journal of the British Diabetic Association·C E de Beaufort, G J Bruining
May 1, 1984·Diabetic Medicine : a Journal of the British Diabetic Association·S A Greene
Nov 1, 1987·Diabetic Medicine : a Journal of the British Diabetic Association·S M MarshallK G Alberti
May 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·C P SmithM O Savage
Jan 1, 1994·Journal of Biomaterials Applications·M J Nitsch, U V Banakar
Apr 4, 1998·The Diabetes Educator·E BolandM Grey
Jul 1, 1982·Cancer·T PlasseJ F Holland

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