Outside looking in: nanotube transistor intracellular sensors.

Nano Letters
Ruixuan GaoCharles M Lieber

Abstract

Nanowire-based field-effect transistors, including devices with planar and three-dimensional configurations, are being actively explored as detectors for extra- and intracellular recording due to their small size and high sensitivities. Here we report the synthesis, fabrication, and characterization of a new needle-shaped nanoprobe based on an active silicon nanotube transistor, ANTT, that enables high-resolution intracellular recording. In the ANTT probe, the source/drain contacts to the silicon nanotube are fabricated on one end, passivated from external solution, and then time-dependent changes in potential can be recorded from the opposite nanotube end via the solution filling the tube. Measurements of conductance versus water-gate potential in aqueous solution show that the ANTT probe is selectively gated by potential changes within the nanotube, thus demonstrating the basic operating principle of the ANTT device. Studies interfacing the ANTT probe with spontaneously beating cardiomyocytes yielded stable intracellular action potentials similar to those reported by other electrophysiological techniques. In addition, the straightforward fabrication of ANTT devices was exploited to prepare multiple ANTT structures at the end ...Continue Reading

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Citations

Jan 16, 2013·Biosensors & Bioelectronics·Minggang ZhaoZhizhen Ye
Aug 2, 2012·ACS Nano·Tzahi Cohen-KarniDaniel S Kohane
Feb 6, 2013·Nature Nanotechnology·Micha E Spira, Aviad Hai
Apr 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jia LiuCharles M Lieber
Jan 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Tian-Ming FuCharles M Lieber
Mar 5, 2013·Annual Review of Analytical Chemistry·Bozhi Tian, Charles M Lieber
Dec 23, 2015·Chemical Reviews·Anqi Zhang, Charles M Lieber
Feb 20, 2013·Current Opinion in Biotechnology·Moria KwiatFernando Patolsky
Aug 15, 2015·Annual Review of Biomedical Engineering·Qing ZhouAlexander Revzin
May 1, 2014·Biomaterials Science·John ZimmermanBozhi Tian
Nov 21, 2019·Advanced Materials·Ying SunKunji Chen
Jan 24, 2014·Beilstein Journal of Nanotechnology·Wei Wei, Timo Jacob
Nov 9, 2016·Reports on Progress in Physics·Wei ZhouCharles M Lieber
Sep 21, 2013·Advanced Materials·Long YangYing Fang
Jul 5, 2019·Nature Nanotechnology·Héctor Acarón LedesmaBozhi Tian
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Aug 16, 2013·Chemistry, an Asian Journal·Xiaojie Duan, Charles M Lieber
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Jan 15, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Steven GibneyFrankie J Rawson
Feb 16, 2021·Frontiers in Bioengineering and Biotechnology·Weiyang YangWen Li

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