Outstanding questions in transplantation: B cells, alloantibodies, and humoral rejection

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Anita S ChongLeonardo V Riella

Abstract

Over the past three decades, improved immunosuppression has significantly reduced T cell-mediated acute rejection rates, but long-term graft survival rates have seen only marginal improvement. The cause of late graft loss has been under intense investigation, and chronic antibody-mediated rejection (AMR) has been identified as one of the leading causes, thus providing a strong rationale for basic science investigation into donor-specific B cells and antibodies in transplantation and ways to mitigate their pathogenicity. In 2018, the American Society of Transplantation launched a community-wide online discussion of Outstanding Questions in Transplantation, and the topic of B cell biology and donor-specific antibody prevention emerged as a major area of interest to the community, leading to a highly engaged dialogue, with comments from basic and translational scientists as well as physicians (http://community.myast.org/communities/community-home/digestviewer). We have summarized this discussion from a bedside to bench perspective and have organized this review into outstanding questions within the paradigm that AMR is a leading cause of graft loss in the clinic, and points of view that challenge aspects of this paradigm. We also ...Continue Reading

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Citations

Dec 29, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Frances T LeeXunrong Luo
Apr 29, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Cynthia S M KramerSebastiaan Heidt
May 15, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Glenn Michael La MuragliaIdelberto Raul Badell
May 21, 2020·International Journal of Molecular Sciences·Sorena B LoNirmala Parajuli
Nov 11, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Robin SchmitzJean Kwun
Jun 17, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Anita S Chong
Dec 12, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Shoko KimuraJames F Markmann
Jul 14, 2021·Immunological Reviews·Amy P RossiE Steve Woodle
Jul 27, 2021·Frontiers in Cell and Developmental Biology·Anita S ChongMaria-Luisa Alegre
Aug 21, 2021·Journal of Immunology Research·Xiaohu LiJinfeng Li

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