Outwitting evolution

Xenotransplantation
David K C Cooper

Abstract

The author pays tribute to those who stimulated him to follow a career in clinical cardiothoracic surgery and experimental transplantation. Highlights of his career have been in contributing to (i) the first hypothermic perfusion storage of the donor heart to be used successfully in clinical practice, (ii) hormonal therapy in the management of the brain-dead potential organ donor, (iii) the identification of Gal alpha 1,3Gal as the major antigenic target for primate natural anti-pig antibodies, (iv) the 2- to 6-month survival of alpha1,3-galactosyltransferase gene-knockout hearts transplanted into baboons, and (v) the 3- to 12-month normoglycemia following the transplantation of islets from CD46-transgenic pigs into diabetic monkeys. Many friends have been made through a mutual interest in transplantation, particularly through the activities of the International Xenotransplantation Association (IXA). The author thanks the many mentors, colleagues, and research fellows with whom it has been his great privilege and pleasure to work during the past several decades, and readily acknowledges that it is largely their contributions that have enabled him to receive the honor of Honorary Membership of the IXA.

References

Mar 1, 1986·The Journal of Surgical Research·W N WicombA G Rose
Oct 19, 1968·British Medical Journal·D K Cooper
Oct 1, 1983·The Annals of Thoracic Surgery·D NovitzkyC N Barnard
Sep 13, 1980·British Medical Journal·T A EnglishR Cory-Pearce
Oct 25, 1980·British Medical Journal·D K CooperC N Barnard
Sep 1, 1995·Nature Medicine·E Cozzi, D J White
Jun 27, 1995·Transplantation·L MielesD K Cooper
Sep 11, 1993·Lancet·D K CooperR Oriol
Jan 1, 1997·Acta Anatomica·K H Wrobel, N Abu-Ghali
Jul 11, 2001·Clinical Cardiology·D K Cooper
Dec 21, 2002·Science·Carol J PhelpsDavid L Ayares
Feb 14, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Kenji KuwakiDavid K C Cooper
May 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·Donna Kolber-SimondsRobert J Hawley
Dec 14, 2006·Transplantation·Dmitri NovitzkyH Myron Kauffman
Feb 1, 2007·Transplantation·Pleunie P M RoodMassimo Trucco
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Davi K C CooperH Myron Kauffman
Oct 3, 2009·Xenotransplantation·Richard N PiersonDavid K C Cooper
Oct 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D J van der WindtM Trucco

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Citations

Jul 23, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Soad M SalehFutwan A Al-Mohanna

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