Oval cells in hepatitis B virus-positive and hepatitis C virus-positive liver cirrhosis: histological and ultrastructural study

Histopathology
C SunJ-C Xiao

Abstract

It is still not clear whether oval cells demonstrate diverse morphology, immunophenotype or quantity in different human liver diseases. The aim of this study was to investigate these differences in hepatitis B virus (HBV)-positive and hepatitis C virus (HCV)-positive human liver cirrhosis (HLC). Thirty-eight cases of HBV+ HLC and 32 cases of HCV+ HLC were investigated by light microscopy and immunohistochemistry for Hepatocyte, CK19, stem cell factor (SCF) and CD34. Five cases were also examined by transmission electron microscopy. Oval cells of similar morphology could be found in proliferating bile ductules in both groups. These cells coexpressed CK19 and Hepatocyte, but did not express SCF or CD34. Some of these cells exhibited a trend towards differentiation. There was no difference in the amount of oval cells between the two groups. The oval cell number was found to increase significantly with the progression of inflammation. A similar stem-like cell was not seen in the normal liver. There are bipotential oval cells in both HBV+ and HCV+ HLC. The lack of difference in oval cells between the two groups suggests that they might play a similar biological role in the histogenesis of different liver diseases.

References

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Citations

May 29, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Francine R DembitzerEllinor I Peerschke
Jan 18, 2014·Cell Death & Disease·K Wang
Jul 23, 2009·European Journal of Gastroenterology & Hepatology·Joanna M LotowskaDariusz M Lebensztejn
Nov 6, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Huafeng WangJiacheng Xiao
Aug 3, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Keisaku SatoGianfranco Alpini
Dec 20, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Beatriz Aguilar-BravoPau Sancho-Bru
Jun 1, 2018·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Elissa M Schechter-PerkinsBenjamin P Linas
Jun 3, 2020·Cell & Bioscience·Mahshid SalehJavad Verdi
Jun 24, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Bu-Gao ZhouDuan-Yong Liu
Jun 14, 2020·Seminars in Cancer Biology·Georgina E RiddioughAli W Majeed

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