PMID: 117067Sep 1, 1979Paper

Ovarian activity, and total gonadotrophin and gonadotrophin releasing hormone levels in response to some synthetic non-steroidal ovulating agents in the catfish, Heteropneustes fossilis (Bloch)

The Journal of Endocrinology
T P Singh, A K Singh

Abstract

Effects of clomiphene citrate, cyclofenil and prostaglandins (PGE1 and PGF2 alpha) on ovarian 32P uptake, on gonadotrophin levels in the pituitary gland and blood serum and on a gonadotrophin releasing hormone-like (GnRH-like) substance in the hypothalamus were investigated in Heteropneustes fossilis. These drugs were very effective in increasing the serum level of gonadotrophin with a subsequent increase in ovarian 32P uptake in sham-hypophysectomized recipients. All the drugs except cyclofenil failed to stimulate 32P incorporation by the ovary in hypophysectomized fish. Clomiphene citrate and cyclofenil also induced a significant increase in the GnRH-like factor in the hypothalamus of H. fossilis. Such a response was not obtained in fish treated with PGE1 and PGF2 alpha. It seems likely that the action of clomiphene is routed through the hypothalamo-pituitary-ovarian axis and that of prostaglandins directly through the pituitary-ovarian axis. The action of cyclofenil is bimodal; one effect like that of clomiphene and the other direct upon the ovary probably by increasing its sensitivity to the available gonadotrophin.

Citations

Jul 1, 1989·Fish Physiology and Biochemistry·L A Van AsseltP G van Oordt
Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J M OlceseV L deVlaming
Jun 1, 1984·General and Comparative Endocrinology·C A HermanK D Doolittle

Related Concepts

Serophene
Ondogyne
Fertility Agents, Female, Hormonal
Pituitary Gonadotropins
Hypophysectomy
Organum Vasculosum Laminae Terminalis
Ovary
Red Phosphorus
Pituitary Stalk
Hypothalamic Releasing Factor

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